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Genetics of Cryptococcus neoformans.

Publication ,  Journal Article
Hull, CM; Heitman, J
Published in: Annu Rev Genet
2002

Cryptococcus neoformans is a pathogenic fungus that primarily afflicts immunocompromised patients, infecting the central nervous system to cause meningoencephalitis that is uniformly fatal if untreated. C. neoformans is a basidiomycetous fungus with a defined sexual cycle that has been linked to differentiation and virulence. Recent advances in classical and molecular genetic approaches have allowed molecular descriptions of the pathways that control cell type and virulence. An ongoing genome sequencing project promises to reveal much about the evolution of this human fungal pathogen into three distinct varieties or species. C. neoformans shares features with both model ascomycetous yeasts (Saccharomyces cerevisiae, Schizosaccharomyces pombe) and basidiomycetous pathogens and mushrooms (Ustilago maydis, Coprinus cinereus, Schizophyllum commune), yet ongoing studies reveal unique features associated with virulence and the arrangement of the mating type locus. These advances have catapulted C. neoformans to center stage as a model of both fungal pathogenesis and the interesting approaches to life that the kingdom of fungi has adopted.

Duke Scholars

Published In

Annu Rev Genet

DOI

ISSN

0066-4197

Publication Date

2002

Volume

36

Start / End Page

557 / 615

Location

United States

Related Subject Headings

  • Signal Transduction
  • Mitogen-Activated Protein Kinases
  • Genes, Mating Type, Fungal
  • Genes, Fungal
  • Developmental Biology
  • Cyclic AMP
  • Cryptococcus neoformans
  • Cell Differentiation
  • Animals
  • 3105 Genetics
 

Citation

APA
Chicago
ICMJE
MLA
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Hull, C. M., & Heitman, J. (2002). Genetics of Cryptococcus neoformans. Annu Rev Genet, 36, 557–615. https://doi.org/10.1146/annurev.genet.36.052402.152652
Hull, Christina M., and Joseph Heitman. “Genetics of Cryptococcus neoformans.Annu Rev Genet 36 (2002): 557–615. https://doi.org/10.1146/annurev.genet.36.052402.152652.
Hull CM, Heitman J. Genetics of Cryptococcus neoformans. Annu Rev Genet. 2002;36:557–615.
Hull, Christina M., and Joseph Heitman. “Genetics of Cryptococcus neoformans.Annu Rev Genet, vol. 36, 2002, pp. 557–615. Pubmed, doi:10.1146/annurev.genet.36.052402.152652.
Hull CM, Heitman J. Genetics of Cryptococcus neoformans. Annu Rev Genet. 2002;36:557–615.

Published In

Annu Rev Genet

DOI

ISSN

0066-4197

Publication Date

2002

Volume

36

Start / End Page

557 / 615

Location

United States

Related Subject Headings

  • Signal Transduction
  • Mitogen-Activated Protein Kinases
  • Genes, Mating Type, Fungal
  • Genes, Fungal
  • Developmental Biology
  • Cyclic AMP
  • Cryptococcus neoformans
  • Cell Differentiation
  • Animals
  • 3105 Genetics