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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.

Publication ,  Journal Article
Kraus, PR; Heitman, J
Published in: Biochem Biophys Res Commun
November 28, 2003

Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress responses in fungi. The functions of calmodulin and calcineurin are largely conserved among pathogenic fungi and model fungi, however, the mechanisms of action have diverged. Saccharomyces cerevisiae is an excellent model for understanding the framework of calcium-mediated signal transduction pathways, and considerable progress has been made in understanding the details of how Ca(2+)-calmodulin and calcineurin control adaptation to environmental stress. Studies using the divergent human pathogenic fungi Candida albicans and Cryptococcus neoformans reveal that calcineurin is critical for virulence, yet it acts via distinct mechanisms in each fungus. These differences in function may reflect the requirements of each pathogen to survive inside the host, and illustrate that studies must be conducted in each organism in order to elucidate the details of the molecular mechanisms of calmodulin and calcineurin-mediated signaling pathways.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

November 28, 2003

Volume

311

Issue

4

Start / End Page

1151 / 1157

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Species Specificity
  • Saccharomyces cerevisiae
  • Gene Expression Regulation, Fungal
  • Fungi
  • Cryptococcus neoformans
  • Candida albicans
  • Calmodulin
  • Calcium Signaling
  • Calcineurin
 

Citation

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MLA
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Kraus, P. R., & Heitman, J. (2003). Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun, 311(4), 1151–1157. https://doi.org/10.1016/s0006-291x(03)01528-6
Kraus, Peter R., and Joseph Heitman. “Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.Biochem Biophys Res Commun 311, no. 4 (November 28, 2003): 1151–57. https://doi.org/10.1016/s0006-291x(03)01528-6.
Kraus PR, Heitman J. Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun. 2003 Nov 28;311(4):1151–7.
Kraus, Peter R., and Joseph Heitman. “Coping with stress: calmodulin and calcineurin in model and pathogenic fungi.Biochem Biophys Res Commun, vol. 311, no. 4, Nov. 2003, pp. 1151–57. Pubmed, doi:10.1016/s0006-291x(03)01528-6.
Kraus PR, Heitman J. Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochem Biophys Res Commun. 2003 Nov 28;311(4):1151–1157.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

November 28, 2003

Volume

311

Issue

4

Start / End Page

1151 / 1157

Location

United States

Related Subject Headings

  • Transcriptional Activation
  • Species Specificity
  • Saccharomyces cerevisiae
  • Gene Expression Regulation, Fungal
  • Fungi
  • Cryptococcus neoformans
  • Candida albicans
  • Calmodulin
  • Calcium Signaling
  • Calcineurin