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Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.

Publication ,  Journal Article
Pan, X; Harashima, T; Heitman, J
Published in: Curr Opin Microbiol
December 2000

In response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous pseudohyphal growth. At least two signaling pathways regulate filamentation. One involves components of the MAP kinase cascade that also regulates mating of haploid cells. The second involves a nutrient-sensing G-protein-coupled receptor that signals via an unusual G(alpha) protein, cAMP and protein kinase A. Recent studies reveal crosstalk between these pathways during pseudohyphal growth. Related MAP kinase and cAMP pathways regulate filamentation and virulence of human and plant fungal pathogens, and represent novel targets for antifungal drug design.

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Published In

Curr Opin Microbiol

DOI

ISSN

1369-5274

Publication Date

December 2000

Volume

3

Issue

6

Start / End Page

567 / 572

Location

England

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Nitrogen
  • Microbiology
  • Membrane Proteins
  • Membrane Glycoproteins
  • MAP Kinase Signaling System
  • Fungal Proteins
 

Citation

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Pan, X., Harashima, T., & Heitman, J. (2000). Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol, 3(6), 567–572. https://doi.org/10.1016/s1369-5274(00)00142-9
Pan, X., T. Harashima, and J. Heitman. “Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.Curr Opin Microbiol 3, no. 6 (December 2000): 567–72. https://doi.org/10.1016/s1369-5274(00)00142-9.
Pan X, Harashima T, Heitman J. Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol. 2000 Dec;3(6):567–72.
Pan, X., et al. “Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae.Curr Opin Microbiol, vol. 3, no. 6, Dec. 2000, pp. 567–72. Pubmed, doi:10.1016/s1369-5274(00)00142-9.
Pan X, Harashima T, Heitman J. Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Curr Opin Microbiol. 2000 Dec;3(6):567–572.
Journal cover image

Published In

Curr Opin Microbiol

DOI

ISSN

1369-5274

Publication Date

December 2000

Volume

3

Issue

6

Start / End Page

567 / 572

Location

England

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Nitrogen
  • Microbiology
  • Membrane Proteins
  • Membrane Glycoproteins
  • MAP Kinase Signaling System
  • Fungal Proteins