Signal-transduction cascades as targets for therapeutic intervention by natural products.
Publication
, Journal Article
Cardenas, ME; Sanfridson, A; Cutler, NS; Heitman, J
Published in: Trends Biotechnol
October 1998
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.
Duke Scholars
Published In
Trends Biotechnol
DOI
ISSN
0167-7799
Publication Date
October 1998
Volume
16
Issue
10
Start / End Page
427 / 433
Location
England
Related Subject Headings
- Wortmannin
- Tacrolimus
- Sirolimus
- Signal Transduction
- Quinones
- Protein Biosynthesis
- Lactams, Macrocyclic
- Immunosuppressive Agents
- Humans
- HSP90 Heat-Shock Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Cardenas, M. E., Sanfridson, A., Cutler, N. S., & Heitman, J. (1998). Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol, 16(10), 427–433. https://doi.org/10.1016/s0167-7799(98)01239-6
Cardenas, M. E., A. Sanfridson, N. S. Cutler, and J. Heitman. “Signal-transduction cascades as targets for therapeutic intervention by natural products.” Trends Biotechnol 16, no. 10 (October 1998): 427–33. https://doi.org/10.1016/s0167-7799(98)01239-6.
Cardenas ME, Sanfridson A, Cutler NS, Heitman J. Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 1998 Oct;16(10):427–33.
Cardenas, M. E., et al. “Signal-transduction cascades as targets for therapeutic intervention by natural products.” Trends Biotechnol, vol. 16, no. 10, Oct. 1998, pp. 427–33. Pubmed, doi:10.1016/s0167-7799(98)01239-6.
Cardenas ME, Sanfridson A, Cutler NS, Heitman J. Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends Biotechnol. 1998 Oct;16(10):427–433.
Published In
Trends Biotechnol
DOI
ISSN
0167-7799
Publication Date
October 1998
Volume
16
Issue
10
Start / End Page
427 / 433
Location
England
Related Subject Headings
- Wortmannin
- Tacrolimus
- Sirolimus
- Signal Transduction
- Quinones
- Protein Biosynthesis
- Lactams, Macrocyclic
- Immunosuppressive Agents
- Humans
- HSP90 Heat-Shock Proteins