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Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics.

Publication ,  Journal Article
Schwartzman, JD; Reller, LB; Wang, WL
Published in: Antimicrob Agents Chemother
April 1977

The proper choice of antibiotic for Clostridium perfringens infections in patients allergic to penicillin is not clear; the usual recommendations and recent in vitro studies disagree. We tested the susceptibility of 57 strains of C. perfringens to eight penicillins, seven cephalosporins, two tetracyclines, clindamycin, chloramphenicol, and rifampin by the agar dilution method. All strains were inhibited by (per milliliter) 4 mug or less of any of the penicillins, chloramphenicol, or clindamycin and 8 mug or less of any of the cephalosporins tested. Penicillin G and amoxicillin inhibited all strains at 0.12 mug or less per ml. Only 54% of the strains were inhibited by 1 mug of tetracycline per ml. Penicillin G remains the drug of first choice for infections with C. perfringens; it need not be added to a regimen containing a penicillinase-resistant penicillin given parenterally in high doses. The cephalosporins should be considered as alternative drugs for penicillin-allergic patients. Clindamycin and chloramphenicol are also effective. Tetracyclines cannot be depended upon in clostridial infections without in vitro testing, which is impracticable for initial empirical therapy.

Duke Scholars

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 1977

Volume

11

Issue

4

Start / End Page

695 / 697

Location

United States

Related Subject Headings

  • Penicillins
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Clostridium perfringens
  • Clostridium Infections
  • Cephalosporins
  • Anti-Bacterial Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schwartzman, J. D., Reller, L. B., & Wang, W. L. (1977). Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics. Antimicrob Agents Chemother, 11(4), 695–697. https://doi.org/10.1128/AAC.11.4.695
Schwartzman, J. D., L. B. Reller, and W. L. Wang. “Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics.Antimicrob Agents Chemother 11, no. 4 (April 1977): 695–97. https://doi.org/10.1128/AAC.11.4.695.
Schwartzman JD, Reller LB, Wang WL. Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics. Antimicrob Agents Chemother. 1977 Apr;11(4):695–7.
Schwartzman, J. D., et al. “Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics.Antimicrob Agents Chemother, vol. 11, no. 4, Apr. 1977, pp. 695–97. Pubmed, doi:10.1128/AAC.11.4.695.
Schwartzman JD, Reller LB, Wang WL. Susceptibility of Clostridium perfringens isolated from human infections to twenty antibiotics. Antimicrob Agents Chemother. 1977 Apr;11(4):695–697.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

April 1977

Volume

11

Issue

4

Start / End Page

695 / 697

Location

United States

Related Subject Headings

  • Penicillins
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
  • Clostridium perfringens
  • Clostridium Infections
  • Cephalosporins
  • Anti-Bacterial Agents
  • 3214 Pharmacology and pharmaceutical sciences
  • 3207 Medical microbiology