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Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates.

Publication ,  Journal Article
Reimer, LG; Mirrett, S; Reller, LB
Published in: Antimicrob Agents Chemother
March 1980

To compare the in vitro activity of moxalactam (LY127935), a new broad-spectrum antimicrobial agent, with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin, each drug was tested against 420 bacterial isolates from the blood of septic patients. Standard broth dilution methods were used to determine minimum inhibitory and bactericidal concentrations. LY127935 was as active as the aminoglycosides against aerobic gram-negative organisms, including Pseudomonas aeruginosa, and was at least 10-fold more active than the other beta-lactam agents against these bacteria. LY127935 was the most active agent tested against Bacteroides fragilis; its activity against all other anaerobic bacteria and Staphylococcus aureus was similar to those of the other agents tested. All streptococci, however, grew at higher concentrations of LY127935 than any other drug, and Streptococcus faecalis and Listeria monocytogenes were not inhibited at the highest concentration tested (minimum inhibitory concentration, > 64 microgram/ml). Although a greater proportion of blood culture isolates were susceptible to LY127935 than to any other drug tested, LY127935 does not have a sufficiently broad spectrum of in vitro activity to be recommended safely alone for empirical treatment of sepsis of unknown etiology.

Duke Scholars

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

March 1980

Volume

17

Issue

3

Start / End Page

412 / 416

Location

United States

Related Subject Headings

  • Tobramycin
  • Ticarcillin
  • Species Specificity
  • Sepsis
  • Piperacillin
  • Penicillins
  • Moxalactam
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans
 

Citation

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Reimer, L. G., Mirrett, S., & Reller, L. B. (1980). Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates. Antimicrob Agents Chemother, 17(3), 412–416. https://doi.org/10.1128/AAC.17.3.412
Reimer, L. G., S. Mirrett, and L. B. Reller. “Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates.Antimicrob Agents Chemother 17, no. 3 (March 1980): 412–16. https://doi.org/10.1128/AAC.17.3.412.
Reimer, L. G., et al. “Comparison of in vitro activity of moxalactam (LY127935) with cefazolin, amikacin, tobramycin, carbenicillin, piperacillin, and ticarcillin against 420 blood culture isolates.Antimicrob Agents Chemother, vol. 17, no. 3, Mar. 1980, pp. 412–16. Pubmed, doi:10.1128/AAC.17.3.412.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

March 1980

Volume

17

Issue

3

Start / End Page

412 / 416

Location

United States

Related Subject Headings

  • Tobramycin
  • Ticarcillin
  • Species Specificity
  • Sepsis
  • Piperacillin
  • Penicillins
  • Moxalactam
  • Microbiology
  • Microbial Sensitivity Tests
  • Humans