dishevelled and armadillo act in the wingless signalling pathway in Drosophila.
Publication
, Journal Article
Noordermeer, J; Klingensmith, J; Perrimon, N; Nusse, R
Published in: Nature
January 6, 1994
The Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
January 6, 1994
Volume
367
Issue
6458
Start / End Page
80 / 83
Location
England
Related Subject Headings
- Wnt1 Protein
- Transcription Factors
- Trans-Activators
- Signal Transduction
- Proto-Oncogene Proteins
- Proteins
- Phosphoproteins
- Male
- Insect Hormones
- Homeodomain Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Noordermeer, J., Klingensmith, J., Perrimon, N., & Nusse, R. (1994). dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature, 367(6458), 80–83. https://doi.org/10.1038/367080a0
Noordermeer, J., J. Klingensmith, N. Perrimon, and R. Nusse. “dishevelled and armadillo act in the wingless signalling pathway in Drosophila.” Nature 367, no. 6458 (January 6, 1994): 80–83. https://doi.org/10.1038/367080a0.
Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994 Jan 6;367(6458):80–3.
Noordermeer, J., et al. “dishevelled and armadillo act in the wingless signalling pathway in Drosophila.” Nature, vol. 367, no. 6458, Jan. 1994, pp. 80–83. Pubmed, doi:10.1038/367080a0.
Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994 Jan 6;367(6458):80–83.
Published In
Nature
DOI
ISSN
0028-0836
Publication Date
January 6, 1994
Volume
367
Issue
6458
Start / End Page
80 / 83
Location
England
Related Subject Headings
- Wnt1 Protein
- Transcription Factors
- Trans-Activators
- Signal Transduction
- Proto-Oncogene Proteins
- Proteins
- Phosphoproteins
- Male
- Insect Hormones
- Homeodomain Proteins