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Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.

Publication ,  Journal Article
Sokol, SY; Klingensmith, J; Perrimon, N; Itoh, K
Published in: Development
June 1995

Signaling factors of the Wnt proto-oncogene family are implicated in dorsal axis formation during vertebrate development, but the molecular mechanism of this process is not known. Studies in Drosophila have indicated that the dishevelled gene product is required for wingless (Wnt1 homolog) signal transduction. We demonstrate that injection of mRNA encoding a Xenopus homolog of dishevelled (Xdsh) into prospective ventral mesodermal cells triggers a complete dorsal axis formation in Xenopus embryos. Lineage tracing experiments show that cells derived from the injected blastomere contribute to anterior and dorsal structures of the induced axis. In contrast to its effect on mesoderm, overexpression of Xdsh mRNA in prospective ectodermal cells triggers anterior neural tissue differentiation. These studies suggest that Wnt signal transduction pathway is conserved between Drosophila and vertebrates and point to a role for maternal Xdsh product in dorsal axis formation and in neural induction.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1995

Volume

121

Issue

6

Start / End Page

1637 / 1647

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Xenopus laevis
  • Xenopus Proteins
  • Wnt1 Protein
  • Wnt Proteins
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
 

Citation

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ICMJE
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Sokol, S. Y., Klingensmith, J., Perrimon, N., & Itoh, K. (1995). Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development, 121(6), 1637–1647. https://doi.org/10.1242/dev.121.6.1637
Sokol, S. Y., J. Klingensmith, N. Perrimon, and K. Itoh. “Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.Development 121, no. 6 (June 1995): 1637–47. https://doi.org/10.1242/dev.121.6.1637.
Sokol SY, Klingensmith J, Perrimon N, Itoh K. Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development. 1995 Jun;121(6):1637–47.
Sokol, S. Y., et al. “Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.Development, vol. 121, no. 6, June 1995, pp. 1637–47. Pubmed, doi:10.1242/dev.121.6.1637.
Sokol SY, Klingensmith J, Perrimon N, Itoh K. Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development. 1995 Jun;121(6):1637–1647.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 1995

Volume

121

Issue

6

Start / End Page

1637 / 1647

Location

England

Related Subject Headings

  • Zebrafish Proteins
  • Xenopus laevis
  • Xenopus Proteins
  • Wnt1 Protein
  • Wnt Proteins
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins