Protein farnesyltransferase.
Publication
, Journal Article
Park, HW; Beese, LS
Published in: Curr Opin Struct Biol
December 1997
In the past year, the crystal structure of alpha beta heterodimeric protein farnesyltransferase from rat was reported to a resolution of 2.25 A. Farnesyltransferase catalyzes the essential post-translational lipidation of Ras and several other cellular signal transduction proteins. The structure provides a foundation for understanding the specificity and mechanism of protein prenylation and may aid in the design of new anticancer therapeutics.
Duke Scholars
Published In
Curr Opin Struct Biol
DOI
ISSN
0959-440X
Publication Date
December 1997
Volume
7
Issue
6
Start / End Page
873 / 880
Location
England
Related Subject Headings
- ras Proteins
- Zinc
- Substrate Specificity
- Rats
- Protein Structure, Secondary
- Protein Prenylation
- Mutagenesis, Site-Directed
- Molecular Sequence Data
- Models, Molecular
- Dimerization
Citation
APA
Chicago
ICMJE
MLA
NLM
Park, H. W., & Beese, L. S. (1997). Protein farnesyltransferase. Curr Opin Struct Biol, 7(6), 873–880. https://doi.org/10.1016/s0959-440x(97)80160-1
Park, H. W., and L. S. Beese. “Protein farnesyltransferase.” Curr Opin Struct Biol 7, no. 6 (December 1997): 873–80. https://doi.org/10.1016/s0959-440x(97)80160-1.
Park HW, Beese LS. Protein farnesyltransferase. Curr Opin Struct Biol. 1997 Dec;7(6):873–80.
Park, H. W., and L. S. Beese. “Protein farnesyltransferase.” Curr Opin Struct Biol, vol. 7, no. 6, Dec. 1997, pp. 873–80. Pubmed, doi:10.1016/s0959-440x(97)80160-1.
Park HW, Beese LS. Protein farnesyltransferase. Curr Opin Struct Biol. 1997 Dec;7(6):873–880.
Published In
Curr Opin Struct Biol
DOI
ISSN
0959-440X
Publication Date
December 1997
Volume
7
Issue
6
Start / End Page
873 / 880
Location
England
Related Subject Headings
- ras Proteins
- Zinc
- Substrate Specificity
- Rats
- Protein Structure, Secondary
- Protein Prenylation
- Mutagenesis, Site-Directed
- Molecular Sequence Data
- Models, Molecular
- Dimerization