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Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans.

Publication ,  Journal Article
LaBar, KS; LeDoux, JE
Published in: Behavioral neuroscience
October 1996

Conditioned fear in rats was assessed for the effects of pretraining amygdala lesions (unilateral vs. bilateral) across unconditioned stimulus (US) modalities (white noise vs. shock). In contrast to sham controls, unilateral amygdala lesions significantly reduced conditioned freezing responses, whereas bilateral amygdala lesions resulted in a nearly complete lack of freezing to both the conditioned stimulus (CS) and the context. The lesion effects were more pronounced for CS conditioning but were consistent across US modalities. It was concluded that white noise can serve as an effective US and that unilateral amygdala lesions attenuate but do not eliminate conditioned fear in rats. The results support our interpretation of a recent fear conditioning study in humans (K. S. LaBar, J. E. LeDoux, D. D. Spencer, & E. A. Phelps, 1995).

Duke Scholars

Published In

Behavioral neuroscience

DOI

EISSN

1939-0084

ISSN

0735-7044

Publication Date

October 1996

Volume

110

Issue

5

Start / End Page

991 / 997

Related Subject Headings

  • Temporal Lobe
  • Retention, Psychology
  • Rats, Sprague-Dawley
  • Rats
  • Psychosurgery
  • Motor Activity
  • Models, Neurological
  • Male
  • Humans
  • Fear
 

Citation

APA
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ICMJE
MLA
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LaBar, K. S., & LeDoux, J. E. (1996). Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans. Behavioral Neuroscience, 110(5), 991–997. https://doi.org/10.1037//0735-7044.110.5.991
LaBar, K. S., and J. E. LeDoux. “Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans.Behavioral Neuroscience 110, no. 5 (October 1996): 991–97. https://doi.org/10.1037//0735-7044.110.5.991.
LaBar, K. S., and J. E. LeDoux. “Partial disruption of fear conditioning in rats with unilateral amygdala damage: correspondence with unilateral temporal lobectomy in humans.Behavioral Neuroscience, vol. 110, no. 5, Oct. 1996, pp. 991–97. Epmc, doi:10.1037//0735-7044.110.5.991.

Published In

Behavioral neuroscience

DOI

EISSN

1939-0084

ISSN

0735-7044

Publication Date

October 1996

Volume

110

Issue

5

Start / End Page

991 / 997

Related Subject Headings

  • Temporal Lobe
  • Retention, Psychology
  • Rats, Sprague-Dawley
  • Rats
  • Psychosurgery
  • Motor Activity
  • Models, Neurological
  • Male
  • Humans
  • Fear