Skip to main content
Journal cover image

Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response.

Publication ,  Journal Article
Burton, GV; Flowers, JL; Cox, EB; Leight, GS; Dent, GA; Geisinger, KR; McCarty, KS
Published in: Breast Cancer Res Treat
December 1987

A monoclonal antibody (H222) prepared against purified estrogen receptor has been demonstrated to be highly specific and sensitive in an immunohistochemical assay for the detection and quantification of estrogen receptor in human breast carcinoma biopsy specimens. To evaluate the clinical applicability of this assay in cytologic specimens, response to therapy in 12 patients with recurrent breast cancer was correlated with H222 antibody localization in specimens obtained by fine needle aspiration biopsy. All 7 patients with positive H222 responded to hormone therapy (1 complete and 3 partial remissions and 3 stable disease), while 1 of 5 patients with negative H222 responded (1 stable disease). This experience suggests a role for immunohistochemical estrogen receptor determinations in prediction of response to hormonal therapy in patients whose tumor is accessible only to aspiration biopsy. Special care in the handling and interpretation of specimens is essential to optimal application of this method.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

December 1987

Volume

10

Issue

3

Start / End Page

287 / 291

Location

Netherlands

Related Subject Headings

  • Receptors, Estrogen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasms, Hormone-Dependent
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Hormones
  • Female
  • Breast Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Burton, G. V., Flowers, J. L., Cox, E. B., Leight, G. S., Dent, G. A., Geisinger, K. R., & McCarty, K. S. (1987). Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response. Breast Cancer Res Treat, 10(3), 287–291. https://doi.org/10.1007/BF01805766
Burton, G. V., J. L. Flowers, E. B. Cox, G. S. Leight, G. A. Dent, K. R. Geisinger, and K. S. McCarty. “Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response.Breast Cancer Res Treat 10, no. 3 (December 1987): 287–91. https://doi.org/10.1007/BF01805766.
Burton GV, Flowers JL, Cox EB, Leight GS, Dent GA, Geisinger KR, et al. Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response. Breast Cancer Res Treat. 1987 Dec;10(3):287–91.
Burton, G. V., et al. “Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response.Breast Cancer Res Treat, vol. 10, no. 3, Dec. 1987, pp. 287–91. Pubmed, doi:10.1007/BF01805766.
Burton GV, Flowers JL, Cox EB, Leight GS, Dent GA, Geisinger KR, McCarty KS. Estrogen receptor determination by monoclonal antibody in fine needle aspiration breast cancer cytologies: a marker of hormone response. Breast Cancer Res Treat. 1987 Dec;10(3):287–291.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

ISSN

0167-6806

Publication Date

December 1987

Volume

10

Issue

3

Start / End Page

287 / 291

Location

Netherlands

Related Subject Headings

  • Receptors, Estrogen
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasms, Hormone-Dependent
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Hormones
  • Female
  • Breast Neoplasms