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"Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass.

Publication ,  Journal Article
Doherty, DC; Ortel, TL; de Bruijn, N; Greenberg, CS; Van Trigt, P
Published in: Anesthesiology
September 1990

Org 10172 provided adequate anticoagulation for this patient. An excellent correlation between anti-factor Xa activity and ACT was observed at the doses used for CPB. If high-dose Org 10172 is used, these data suggest that it may be possible to circumvent the measurement of anti-factor Xa activity by using the ACT as an index of this heparinoid's anticoagulant effect. Because postoperative bleeding may be excessive, however, development of a method of reversal of Org 10172 is desirable. Although the optimal ACT, dose, plasma concentration, and means of reversal (e.g., protamine vs. heparinase) remains to be determined, heparinoids provide an alternate means of anticoagulation for CPB in patients unable to receive standard heparin.

Duke Scholars

Published In

Anesthesiology

ISSN

0003-3022

Publication Date

September 1990

Volume

73

Issue

3

Start / End Page

562 / 565

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Heparitin Sulfate
  • Heparinoids
  • Glycosaminoglycans
  • Fibrinolytic Agents
  • Dermatan Sulfate
  • Chondroitin Sulfates
  • Cardiopulmonary Bypass
 

Citation

APA
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ICMJE
MLA
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Doherty, D. C., Ortel, T. L., de Bruijn, N., Greenberg, C. S., & Van Trigt, P. (1990). "Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. Anesthesiology, 73(3), 562–565.
Doherty, D. C., T. L. Ortel, N. de Bruijn, C. S. Greenberg, and P. Van Trigt. “"Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass.Anesthesiology 73, no. 3 (September 1990): 562–65.
Doherty DC, Ortel TL, de Bruijn N, Greenberg CS, Van Trigt P. "Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. Anesthesiology. 1990 Sep;73(3):562–5.
Doherty DC, Ortel TL, de Bruijn N, Greenberg CS, Van Trigt P. "Heparin-free" cardiopulmonary bypass: first reported use of heparinoid (Org 10172) to provide anticoagulation for cardiopulmonary bypass. Anesthesiology. 1990 Sep;73(3):562–565.

Published In

Anesthesiology

ISSN

0003-3022

Publication Date

September 1990

Volume

73

Issue

3

Start / End Page

562 / 565

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Heparitin Sulfate
  • Heparinoids
  • Glycosaminoglycans
  • Fibrinolytic Agents
  • Dermatan Sulfate
  • Chondroitin Sulfates
  • Cardiopulmonary Bypass