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Current status of endocrine therapy for metastatic breast cancer.

Publication ,  Journal Article
Kimmick, G; Muss, HB
Published in: Oncology (Williston Park)
September 1995

Hormonal manipulation is currently the mainstay of palliative care for metastatic breast cancer because it is well tolerated and produces significant responses in approximately one-third of unselected patients. Tamoxifen, a nonsteroidal antiestrogen, is currently considered first-line therapy. Second-line agents include progestins and aromatase inhibitors. New agents, such as the "pure" antiestrogens and the gonadotropin-releasing hormone (GnRH) agonists, are being tested. Other approaches for affecting the hormonal milieu are also under investigation, including combinations of hormonal agents, hormonal agents plus biologics, and hormonal agents plus antiproliferative agents. This review will address the basis for endocrine therapy and possible mechanisms of hormonal resistance, currently available agents and newer ones on the horizon, and areas of future interest.

Duke Scholars

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

September 1995

Volume

9

Issue

9

Start / End Page

877 / 890

Location

United States

Related Subject Headings

  • Premenopause
  • Postmenopause
  • Ovariectomy
  • Neoplasms, Hormone-Dependent
  • Neoplasm Metastasis
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Agents, Hormonal
 

Citation

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Kimmick, G., & Muss, H. B. (1995). Current status of endocrine therapy for metastatic breast cancer. Oncology (Williston Park), 9(9), 877–890.
Kimmick, G., and H. B. Muss. “Current status of endocrine therapy for metastatic breast cancer.Oncology (Williston Park) 9, no. 9 (September 1995): 877–90.
Kimmick G, Muss HB. Current status of endocrine therapy for metastatic breast cancer. Oncology (Williston Park). 1995 Sep;9(9):877–90.
Kimmick, G., and H. B. Muss. “Current status of endocrine therapy for metastatic breast cancer.Oncology (Williston Park), vol. 9, no. 9, Sept. 1995, pp. 877–90.
Kimmick G, Muss HB. Current status of endocrine therapy for metastatic breast cancer. Oncology (Williston Park). 1995 Sep;9(9):877–890.

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

September 1995

Volume

9

Issue

9

Start / End Page

877 / 890

Location

United States

Related Subject Headings

  • Premenopause
  • Postmenopause
  • Ovariectomy
  • Neoplasms, Hormone-Dependent
  • Neoplasm Metastasis
  • Humans
  • Female
  • Breast Neoplasms
  • Antineoplastic Agents, Hormonal