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Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat.

Publication ,  Journal Article
Sostman, HD; Gore, JC; Flye, MW; Johnson, GA; Herfkens, RJ
Published in: Hepatology
1985

We studied the proton T1 and T2, water and lipid content of regenerating rat liver from 1 to 7 days after 70% hepatectomy. Liver from normal and sham-operated animals and splenic tissue from all animals were studied as controls. In vivo proton spectroscopy and imaging of liver was performed in a separate group of control and posthepatectomy rats. The T2 of regenerating liver, but not of sham or normal control liver, was prolonged. Changes in T1, relative to normal tissue, were found in liver and spleen of both operated groups. Lipid content, assessed both by extraction of tissue samples and by in vivo spectroscopy, was increased in regenerating tissue but not in controls. Water content was similarly increased in regenerating liver tissue. Changes in water and lipid content appeared to contribute to the alterations in proton relaxation which we observed.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

1985

Volume

5

Issue

4

Start / End Page

538 / 543

Location

United States

Related Subject Headings

  • Time Factors
  • Spleen
  • Spectrum Analysis
  • Rats, Inbred Strains
  • Rats
  • Protons
  • Male
  • Magnetic Resonance Spectroscopy
  • Liver Regeneration
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sostman, H. D., Gore, J. C., Flye, M. W., Johnson, G. A., & Herfkens, R. J. (1985). Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat. Hepatology, 5(4), 538–543. https://doi.org/10.1002/hep.1840050403
Sostman, H. D., J. C. Gore, M. W. Flye, G. A. Johnson, and R. J. Herfkens. “Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat.Hepatology 5, no. 4 (1985): 538–43. https://doi.org/10.1002/hep.1840050403.
Sostman HD, Gore JC, Flye MW, Johnson GA, Herfkens RJ. Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat. Hepatology. 1985;5(4):538–43.
Sostman, H. D., et al. “Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat.Hepatology, vol. 5, no. 4, 1985, pp. 538–43. Pubmed, doi:10.1002/hep.1840050403.
Sostman HD, Gore JC, Flye MW, Johnson GA, Herfkens RJ. Time course and mechanism of alterations in proton relaxation during liver regeneration in the rat. Hepatology. 1985;5(4):538–543.
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

1985

Volume

5

Issue

4

Start / End Page

538 / 543

Location

United States

Related Subject Headings

  • Time Factors
  • Spleen
  • Spectrum Analysis
  • Rats, Inbred Strains
  • Rats
  • Protons
  • Male
  • Magnetic Resonance Spectroscopy
  • Liver Regeneration
  • Liver