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Magnetic resonance microscopy of embryos.

Publication ,  Journal Article
Smith, BR; Linney, E; Huff, DS; Johnson, GA
Published in: Comput Med Imaging Graph
1996
Published version (DOI) Link to item

We demonstrate that magnetic resonance (MR) microscopy provides a mechanism to investigate normal and abnormal developmental anatomy in a non-destructive and distortion-free manner. Techniques for the fixation, embedding, perfusion and image acquisition of embryos between 3 and 30 mm crown rump length are described. We describe the perfusion of a contrast agent to enhance images of the developing embryonic vasculature. Data are acquired as three-dimensional isotropic arrays which permit images to be reformatted retrospectively in any plane. The data are available for archiving, distributing and for post-acquisition manipulations. MR microscopy is a fast technique for producing three-dimensional reconstructions and is free from registration and sectioning artifacts.

Duke Scholars

Elwood Albert Linney
Author Elwood Albert Linney Molecular Genetics and Microbiology
G. Allan Johnson
Author G. Allan Johnson Radiology

Published In

Comput Med Imaging Graph

DOI

10.1016/s0895-6111(96)00046-8

ISSN

0895-6111

Publication Date

1996

Volume

20

Issue

6

Start / End Page

483 / 490

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Medical Illustration
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Embryonic and Fetal Development
  • Embryo, Mammalian
  • Databases, Factual
 

Citation

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ICMJE
MLA
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Smith, B. R., Linney, E., Huff, D. S., & Johnson, G. A. (1996). Magnetic resonance microscopy of embryos. Comput Med Imaging Graph, 20(6), 483–490. https://doi.org/10.1016/s0895-6111(96)00046-8
Smith, B. R., E. Linney, D. S. Huff, and G. A. Johnson. “Magnetic resonance microscopy of embryos.” Comput Med Imaging Graph 20, no. 6 (1996): 483–90. https://doi.org/10.1016/s0895-6111(96)00046-8.
Smith BR, Linney E, Huff DS, Johnson GA. Magnetic resonance microscopy of embryos. Comput Med Imaging Graph. 1996;20(6):483–90.
Smith, B. R., et al. “Magnetic resonance microscopy of embryos.” Comput Med Imaging Graph, vol. 20, no. 6, 1996, pp. 483–90. Pubmed, doi:10.1016/s0895-6111(96)00046-8.
Smith BR, Linney E, Huff DS, Johnson GA. Magnetic resonance microscopy of embryos. Comput Med Imaging Graph. 1996;20(6):483–490.
Journal cover image

Published In

Comput Med Imaging Graph

DOI

10.1016/s0895-6111(96)00046-8

ISSN

0895-6111

Publication Date

1996

Volume

20

Issue

6

Start / End Page

483 / 490

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Microscopy
  • Mice
  • Medical Illustration
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Embryonic and Fetal Development
  • Embryo, Mammalian
  • Databases, Factual