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Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1).

Publication ,  Journal Article
Möller, HE; Hedlund, LW; Chen, XJ; Carey, MR; Chawla, MS; Wheeler, CT; Johnson, GA
Published in: Magn Reson Med
March 2001

Hyperpolarized (3)He spin-lattice relaxation was investigated in the guinea pig lung using spectroscopy and imaging techniques with a repetitive RF pulse series. T(1) was dominated by interactions with oxygen and was used to measure the alveolar O(2) partial pressure. In animals ventilated with a mixture of 79% (3)He and 21% O(2), T(1) dropped from 19.6 sec in vivo to 14.6 sec after cardiac arrest, reflecting the termination of the intrapulmonary gas exchange. The initial difference in oxygen concentration between inspired and alveolar air, and the temporal decay during apnea were related to functional parameters. Estimates of oxygen uptake were 29 +/- 11 mL min(-1) kg(-1) under normoxic conditions, and 9.0 +/- 2.0 mL min(-1) kg(-1) under hypoxic conditions. Cardiac output was estimated to be 400 +/- 160 mL min(-1) kg(-1). The functional residual capacity derived from spirometric magnetic resonance experiments varied with body mass between 5.4 +/- 0.3 mL and 10.7 +/- 1.1 mL. Magn Reson Med 45:421-430, 2001.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2001

Volume

45

Issue

3

Start / End Page

421 / 430

Location

United States

Related Subject Headings

  • Pulmonary Gas Exchange
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Lung
  • Isotopes
  • Image Enhancement
  • Helium
  • Heart Arrest, Induced
  • Guinea Pigs
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Möller, H. E., Hedlund, L. W., Chen, X. J., Carey, M. R., Chawla, M. S., Wheeler, C. T., & Johnson, G. A. (2001). Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1). Magn Reson Med, 45(3), 421–430. https://doi.org/10.1002/1522-2594(200103)45:3<421::aid-mrm1055>3.0.co;2-k
Möller, H. E., L. W. Hedlund, X. J. Chen, M. R. Carey, M. S. Chawla, C. T. Wheeler, and G. A. Johnson. “Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1).Magn Reson Med 45, no. 3 (March 2001): 421–30. https://doi.org/10.1002/1522-2594(200103)45:3<421::aid-mrm1055>3.0.co;2-k.
Möller HE, Hedlund LW, Chen XJ, Carey MR, Chawla MS, Wheeler CT, et al. Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1). Magn Reson Med. 2001 Mar;45(3):421–30.
Möller, H. E., et al. “Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1).Magn Reson Med, vol. 45, no. 3, Mar. 2001, pp. 421–30. Pubmed, doi:10.1002/1522-2594(200103)45:3<421::aid-mrm1055>3.0.co;2-k.
Möller HE, Hedlund LW, Chen XJ, Carey MR, Chawla MS, Wheeler CT, Johnson GA. Measurements of hyperpolarized gas properties in the lung. Part III: (3)He T(1). Magn Reson Med. 2001 Mar;45(3):421–430.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

March 2001

Volume

45

Issue

3

Start / End Page

421 / 430

Location

United States

Related Subject Headings

  • Pulmonary Gas Exchange
  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Spectroscopy
  • Lung
  • Isotopes
  • Image Enhancement
  • Helium
  • Heart Arrest, Induced
  • Guinea Pigs