New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii
Publication
, Journal Article
Perry, TL; Dickerson, A; Khan, AA; Kondru, RK; Beratan, DN; Wipf, P; Kelly, M; Hamann, MT
Published in: Tetrahedron
February 18, 2001
An analysis of the chemical constituents of Plakinastrella onkodes collected in Jamaica yielded three cyclic peroxides, including the known plakortolide (1) and two new analogs of 1. The absolute configuration of plakortolide G ((3R,4R,6R,8S)-3) was determined by ab initio optical rotation computations using a coupled Hartree-Fock (CHF) method implemented in CADPAC. Plakortolide (1) (J. Org. Chem. 1980, 45, 3396) and plakortolide G (3) exhibited potent inhibitory activity against the protozoan Toxoplasma gondii in HFF cells and represent the first marine natural products reported with T. gondii inhibitory activity. © 2001 Elsevier Science Ltd.
Duke Scholars
Published In
Tetrahedron
DOI
ISSN
0040-4020
Publication Date
February 18, 2001
Volume
57
Issue
8
Start / End Page
1483 / 1487
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Perry, T. L., Dickerson, A., Khan, A. A., Kondru, R. K., Beratan, D. N., Wipf, P., … Hamann, M. T. (2001). New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron, 57(8), 1483–1487. https://doi.org/10.1016/S0040-4020(00)01134-0
Perry, T. L., A. Dickerson, A. A. Khan, R. K. Kondru, D. N. Beratan, P. Wipf, M. Kelly, and M. T. Hamann. “New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii.” Tetrahedron 57, no. 8 (February 18, 2001): 1483–87. https://doi.org/10.1016/S0040-4020(00)01134-0.
Perry TL, Dickerson A, Khan AA, Kondru RK, Beratan DN, Wipf P, et al. New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron. 2001 Feb 18;57(8):1483–7.
Perry, T. L., et al. “New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii.” Tetrahedron, vol. 57, no. 8, Feb. 2001, pp. 1483–87. Scopus, doi:10.1016/S0040-4020(00)01134-0.
Perry TL, Dickerson A, Khan AA, Kondru RK, Beratan DN, Wipf P, Kelly M, Hamann MT. New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii. Tetrahedron. 2001 Feb 18;57(8):1483–1487.
Published In
Tetrahedron
DOI
ISSN
0040-4020
Publication Date
February 18, 2001
Volume
57
Issue
8
Start / End Page
1483 / 1487
Related Subject Headings
- Organic Chemistry
- 3405 Organic chemistry
- 3404 Medicinal and biomolecular chemistry
- 3101 Biochemistry and cell biology
- 0305 Organic Chemistry
- 0304 Medicinal and Biomolecular Chemistry