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Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.

Publication ,  Journal Article
Benveniste, H; Einstein, G; Kim, KR; Hulette, C; Johnson, GA
Published in: Proc Natl Acad Sci U S A
November 23, 1999

Magnetic resonance microscopy (MRM) theoretically provides the spatial resolution and signal-to-noise ratio needed to resolve neuritic plaques, the neuropathological hallmark of Alzheimer's disease (AD). Two previously unexplored MR contrast parameters, T2* and diffusion, are tested for plaque-specific contrast to noise. Autopsy specimens from nondemented controls (n = 3) and patients with AD (n = 5) were used. Three-dimensional T2* and diffusion MR images with voxel sizes ranging from 3 x 10(-3) mm(3) to 5.9 x 10(-5) mm(3) were acquired. After imaging, specimens were cut and stained with a microwave king silver stain to demonstrate neuritic plaques. From controls, the alveus, fimbria, pyramidal cell layer, hippocampal sulcus, and granule cell layer were detected by either T2* or diffusion contrast. These structures were used as landmarks when correlating MRMs with histological sections. At a voxel resolution of 5.9 x 10(-5) mm(3), neuritic plaques could be detected by T2*. The neuritic plaques emerged as black, spherical elements on T2* MRMs and could be distinguished from vessels only in cross-section when presented in three dimension. Here we provide MR images of neuritic plaques in vitro. The MRM results reported provide a new direction for applying this technology in vivo. Clearly, the ability to detect and follow the early progression of amyloid-positive brain lesions will greatly aid and simplify the many possibilities to intervene pharmacologically in AD.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 23, 1999

Volume

96

Issue

24

Start / End Page

14079 / 14084

Location

United States

Related Subject Headings

  • Protons
  • Plaque, Amyloid
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Coloring Agents
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged
 

Citation

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ICMJE
MLA
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Benveniste, H., Einstein, G., Kim, K. R., Hulette, C., & Johnson, G. A. (1999). Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci U S A, 96(24), 14079–14084. https://doi.org/10.1073/pnas.96.24.14079
Benveniste, H., G. Einstein, K. R. Kim, C. Hulette, and G. A. Johnson. “Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.Proc Natl Acad Sci U S A 96, no. 24 (November 23, 1999): 14079–84. https://doi.org/10.1073/pnas.96.24.14079.
Benveniste H, Einstein G, Kim KR, Hulette C, Johnson GA. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14079–84.
Benveniste, H., et al. “Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.Proc Natl Acad Sci U S A, vol. 96, no. 24, Nov. 1999, pp. 14079–84. Pubmed, doi:10.1073/pnas.96.24.14079.
Benveniste H, Einstein G, Kim KR, Hulette C, Johnson GA. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14079–14084.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 23, 1999

Volume

96

Issue

24

Start / End Page

14079 / 14084

Location

United States

Related Subject Headings

  • Protons
  • Plaque, Amyloid
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Coloring Agents
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged