Skip to main content
Journal cover image

Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.

Publication ,  Journal Article
Wellons, MF; Ottinger, JS; Weinhold, KJ; Gryszowka, V; Sanders, LL; Edwards, LJ; Gooding, ME; Thomasch, JR; Bartlett, JA
Published in: J Infect Dis
May 15, 2001

A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels.

Duke Scholars

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

May 15, 2001

Volume

183

Issue

10

Start / End Page

1522 / 1525

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Remission Induction
  • Recurrence
  • RNA, Viral
  • Middle Aged
  • Microbiology
  • Male
  • Lymphocyte Activation
  • Immunophenotyping
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wellons, M. F., Ottinger, J. S., Weinhold, K. J., Gryszowka, V., Sanders, L. L., Edwards, L. J., … Bartlett, J. A. (2001). Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. J Infect Dis, 183(10), 1522–1525. https://doi.org/10.1086/320193
Wellons, M. F., J. S. Ottinger, K. J. Weinhold, V. Gryszowka, L. L. Sanders, L. J. Edwards, M. E. Gooding, J. R. Thomasch, and J. A. Bartlett. “Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.J Infect Dis 183, no. 10 (May 15, 2001): 1522–25. https://doi.org/10.1086/320193.
Wellons MF, Ottinger JS, Weinhold KJ, Gryszowka V, Sanders LL, Edwards LJ, et al. Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. J Infect Dis. 2001 May 15;183(10):1522–5.
Wellons, M. F., et al. “Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.J Infect Dis, vol. 183, no. 10, May 2001, pp. 1522–25. Pubmed, doi:10.1086/320193.
Wellons MF, Ottinger JS, Weinhold KJ, Gryszowka V, Sanders LL, Edwards LJ, Gooding ME, Thomasch JR, Bartlett JA. Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. J Infect Dis. 2001 May 15;183(10):1522–1525.
Journal cover image

Published In

J Infect Dis

DOI

ISSN

0022-1899

Publication Date

May 15, 2001

Volume

183

Issue

10

Start / End Page

1522 / 1525

Location

United States

Related Subject Headings

  • T-Lymphocyte Subsets
  • Remission Induction
  • Recurrence
  • RNA, Viral
  • Middle Aged
  • Microbiology
  • Male
  • Lymphocyte Activation
  • Immunophenotyping
  • Humans