Skip to main content
Journal cover image

A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago.

Publication ,  Journal Article
Cleghorn, FR; Jack, N; Carr, JK; Edwards, J; Mahabir, B; Sill, A; McDanal, CB; Connolly, SM; Goodman, D; Bennetts, RQ; O'Brien, TR ...
Published in: Proc Natl Acad Sci U S A
September 12, 2000

HIV-1 transmission worldwide is predominantly associated with heterosexual activity, and non-clade B viruses account for the most spread. The HIV-1 epidemic in Trinidad/Tobago and the Caribbean shares many features with such heterosexual epidemics, including a prominent role for coincident sexually transmitted diseases. This study evaluates the molecular epidemiology of HIV-1 in Trinidad/Tobago during a period when abrupt transition from homosexual to heterosexual transmission occurred in the absence of injecting drug use, concomitant with a rapid rise in HIV-1 prevalence in the heterosexual population. Of 31 viral isolates studied during 1987-1995, all cluster with subtype B reference strains. In the analysis of full env genes from 22 early seroconverters, the Trinidad isolates constitute a significant subcluster within the B subtype. The Trinidad V3 consensus sequence differs by a single amino acid from the prototype B V3 consensus and demonstrates stability over the decade of this study. In the majority of isolates, the V3 loop of env contains a signature threonine deletion that marks the lineage of the Trinidad HIV-1 clade B epidemic from pre-1984. No phenotypic features, including syncitium induction, neutralization profiles, and chemokine receptor usage, distinguish this virus population from other subtype B viruses. Thus, although the subtype B HIV-1 viruses being transmitted in Trinidad are genetically distinguishable from other subtype B viruses, this is probably the result of a strong founder effect in a geographically circumscribed population rather than genetic selection for heterosexual transmission. These results demonstrate that canonical clade B HIV-1 can generate a typical heterosexual epidemic.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 12, 2000

Volume

97

Issue

19

Start / End Page

10532 / 10537

Location

United States

Related Subject Headings

  • Trinidad and Tobago
  • Species Specificity
  • Sexual Behavior
  • Sequence Homology, Amino Acid
  • Peptide Fragments
  • Molecular Sequence Data
  • Male
  • Humans
  • HIV-1
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cleghorn, F. R., Jack, N., Carr, J. K., Edwards, J., Mahabir, B., Sill, A., … Greenberg, M. L. (2000). A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago. Proc Natl Acad Sci U S A, 97(19), 10532–10537. https://doi.org/10.1073/pnas.97.19.10532
Cleghorn, F. R., N. Jack, J. K. Carr, J. Edwards, B. Mahabir, A. Sill, C. B. McDanal, et al. “A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago.Proc Natl Acad Sci U S A 97, no. 19 (September 12, 2000): 10532–37. https://doi.org/10.1073/pnas.97.19.10532.
Cleghorn FR, Jack N, Carr JK, Edwards J, Mahabir B, Sill A, et al. A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10532–7.
Cleghorn, F. R., et al. “A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago.Proc Natl Acad Sci U S A, vol. 97, no. 19, Sept. 2000, pp. 10532–37. Pubmed, doi:10.1073/pnas.97.19.10532.
Cleghorn FR, Jack N, Carr JK, Edwards J, Mahabir B, Sill A, McDanal CB, Connolly SM, Goodman D, Bennetts RQ, O’Brien TR, Weinhold KJ, Bartholomew C, Blattner WA, Greenberg ML. A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10532–10537.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 12, 2000

Volume

97

Issue

19

Start / End Page

10532 / 10537

Location

United States

Related Subject Headings

  • Trinidad and Tobago
  • Species Specificity
  • Sexual Behavior
  • Sequence Homology, Amino Acid
  • Peptide Fragments
  • Molecular Sequence Data
  • Male
  • Humans
  • HIV-1
  • HIV Infections