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The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene.

Publication ,  Journal Article
Econs, MJ; Pericak-Vance, MA; Betz, H; Bartlett, RJ; Speer, MC; Drezner, MK
Published in: Genomics
July 1990

We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5' untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(theta) = 7.91 at theta = 0.07] and confirmed linkage between HYP and DXS41 [Z(theta) = 8.31 at theta = 0.06] and DXS43 [Z(theta) = 5.94 at theta = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(theta) = 5.40 at theta = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-(GLR/DSX43).

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

July 1990

Volume

7

Issue

3

Start / End Page

439 / 441

Location

United States

Related Subject Headings

  • X Chromosome
  • Receptors, Neurotransmitter
  • Receptors, Glycine
  • Male
  • Lod Score
  • Hypophosphatemia, Familial
  • Humans
  • Glycine
  • Genetics & Heredity
  • Genetic Markers
 

Citation

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Econs, M. J., Pericak-Vance, M. A., Betz, H., Bartlett, R. J., Speer, M. C., & Drezner, M. K. (1990). The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. Genomics, 7(3), 439–441. https://doi.org/10.1016/0888-7543(90)90180-3
Econs, M. J., M. A. Pericak-Vance, H. Betz, R. J. Bartlett, M. C. Speer, and M. K. Drezner. “The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene.Genomics 7, no. 3 (July 1990): 439–41. https://doi.org/10.1016/0888-7543(90)90180-3.
Econs MJ, Pericak-Vance MA, Betz H, Bartlett RJ, Speer MC, Drezner MK. The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. Genomics. 1990 Jul;7(3):439–41.
Econs, M. J., et al. “The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene.Genomics, vol. 7, no. 3, July 1990, pp. 439–41. Pubmed, doi:10.1016/0888-7543(90)90180-3.
Econs MJ, Pericak-Vance MA, Betz H, Bartlett RJ, Speer MC, Drezner MK. The human glycine receptor: a new probe that is linked to the X-linked hypophosphatemic rickets gene. Genomics. 1990 Jul;7(3):439–441.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

July 1990

Volume

7

Issue

3

Start / End Page

439 / 441

Location

United States

Related Subject Headings

  • X Chromosome
  • Receptors, Neurotransmitter
  • Receptors, Glycine
  • Male
  • Lod Score
  • Hypophosphatemia, Familial
  • Humans
  • Glycine
  • Genetics & Heredity
  • Genetic Markers