Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1).
Publication
, Journal Article
Seizinger, BR; Farmer, GE; Haines, JL; Ozelius, LJ; Anderson, K; Korf, BR; Parry, DM; Pericak-Vance, MA; Mulvihill, JJ; Menon, A
Published in: Am J Hum Genet
January 1989
The defective gene causing von Recklinghausen neurofibromatosis (NF1), one of the most common inherited disorders affecting the human nervous system, was recently mapped to chromosome 17. We have used additional DNA markers to further narrow and bracket the NF1 defect. A multipoint linkage analysis suggests that the NF1 gene is flanked by D17Z1 on the centromeric side and by EW 207 on the telomeric side of the long arm of chromosome 17. The identification of closely linked flanking markers should allow us to develop a reliable prenatal and presymptomatic diagnostic test for this serious neurological disorder and provides the basis for applying chromosome-specific cloning techniques for the isolation and characterization of the mutant gene.
Duke Scholars
Published In
Am J Hum Genet
ISSN
0002-9297
Publication Date
January 1989
Volume
44
Issue
1
Start / End Page
30 / 32
Location
United States
Related Subject Headings
- Neurofibromatosis 1
- Humans
- Genetics & Heredity
- Genetic Markers
- Genetic Linkage
- Chromosomes, Human, Pair 17
- Chromosome Mapping
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Seizinger, B. R., Farmer, G. E., Haines, J. L., Ozelius, L. J., Anderson, K., Korf, B. R., … Menon, A. (1989). Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1). Am J Hum Genet, 44(1), 30–32.
Seizinger, B. R., G. E. Farmer, J. L. Haines, L. J. Ozelius, K. Anderson, B. R. Korf, D. M. Parry, M. A. Pericak-Vance, J. J. Mulvihill, and A. Menon. “Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1).” Am J Hum Genet 44, no. 1 (January 1989): 30–32.
Seizinger BR, Farmer GE, Haines JL, Ozelius LJ, Anderson K, Korf BR, et al. Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1). Am J Hum Genet. 1989 Jan;44(1):30–2.
Seizinger, B. R., et al. “Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1).” Am J Hum Genet, vol. 44, no. 1, Jan. 1989, pp. 30–32.
Seizinger BR, Farmer GE, Haines JL, Ozelius LJ, Anderson K, Korf BR, Parry DM, Pericak-Vance MA, Mulvihill JJ, Menon A. Flanking markers for the gene causing von Recklinghausen neurofibromatosis (NF1). Am J Hum Genet. 1989 Jan;44(1):30–32.
Published In
Am J Hum Genet
ISSN
0002-9297
Publication Date
January 1989
Volume
44
Issue
1
Start / End Page
30 / 32
Location
United States
Related Subject Headings
- Neurofibromatosis 1
- Humans
- Genetics & Heredity
- Genetic Markers
- Genetic Linkage
- Chromosomes, Human, Pair 17
- Chromosome Mapping
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences