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Linkage and association analysis of chromosome 19q13 in multiple sclerosis.
Multiple sclerosis (MS) is an autoimmune neurological disorder with a complex etiology. Sibling risk, twin, and adoption studies have demonstrated that genes play a vital role in susceptibility to MS. Numerous association and linkage studies have implicated the major histocompatibility complex (MHC) as one component of the genetic etiology, but additional loci remain to be identified. Genomic screens have suggested over 50 regions that might harbor these genes, but there has been little agreement between studies. The one region suggested by all four screens resides within chromosome 19q13. Allelic associations with several markers in this region have also been described. This region has now been examined in detail in an expanded dataset of MS families from the United States. Genetic linkage and association were tested with multiple markers in this region using both parametric and non-parametric analyses. Additional support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele. While consistent, this effect appears to be modest with a maximum lambda(s) = 1.47, probably representing no more than 10% of the overall genetic effect in MS.
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Related Subject Headings
- Neurology & Neurosurgery
- Multiple Sclerosis
- Lod Score
- Humans
- Family Health
- Chromosomes, Human, Pair 19
- 3209 Neurosciences
- 3202 Clinical sciences
- 3105 Genetics
- 1702 Cognitive Sciences
Citation
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=1364-6745&client=dukeuniv)
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Neurology & Neurosurgery
- Multiple Sclerosis
- Lod Score
- Humans
- Family Health
- Chromosomes, Human, Pair 19
- 3209 Neurosciences
- 3202 Clinical sciences
- 3105 Genetics
- 1702 Cognitive Sciences