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Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases.

Publication ,  Journal Article
Johnson, LB; Krebs, TL; Van Echo, D; Plotkin, JS; Njoku, M; Wong, JJ; Daly, BD; Kuo, PC
Published in: Am J Surg
December 1997

BACKGROUND: Cryosurgery can be employed in patients with unresectable hepatic metastases when the tumor size and the number of metastases are limited. However, local recurrence can result from incomplete ablation. We proposed a trial of complete cytoablation with a combined approach of cryosurgery and hepatic resection for patients with bilobar hepatic metastases. METHODS: Seven patients underwent cryosurgery alone (CRYO). Seven additional patients underwent combined resection and cryosurgery (CRYO+RES) for bilobar metastases. RESULTS: In the CRYO group, 5 of 7 patients had at least one centrally located tumor. All 5 of these patients had early recurrence at the site of ablation. In the CRYO+RES group complete ablation was achieved in 7 of 7. Two (28.6%) of these patients developed local recurrence. CONCLUSION: Cytoablation of hepatic metastases can be safely achieved with combined hepatic resection and cryosurgery in selected patients. Long-term survival data are necessary before advocating widespread application of this approach.

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Published In

Am J Surg

DOI

ISSN

0002-9610

Publication Date

December 1997

Volume

174

Issue

6

Start / End Page

610 / 613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Female
 

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Johnson, L. B., Krebs, T. L., Van Echo, D., Plotkin, J. S., Njoku, M., Wong, J. J., … Kuo, P. C. (1997). Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases. Am J Surg, 174(6), 610–613. https://doi.org/10.1016/s0002-9610(97)00176-1
Johnson, L. B., T. L. Krebs, D. Van Echo, J. S. Plotkin, M. Njoku, J. J. Wong, B. D. Daly, and P. C. Kuo. “Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases.Am J Surg 174, no. 6 (December 1997): 610–13. https://doi.org/10.1016/s0002-9610(97)00176-1.
Johnson LB, Krebs TL, Van Echo D, Plotkin JS, Njoku M, Wong JJ, et al. Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases. Am J Surg. 1997 Dec;174(6):610–3.
Johnson, L. B., et al. “Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases.Am J Surg, vol. 174, no. 6, Dec. 1997, pp. 610–13. Pubmed, doi:10.1016/s0002-9610(97)00176-1.
Johnson LB, Krebs TL, Van Echo D, Plotkin JS, Njoku M, Wong JJ, Daly BD, Kuo PC. Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases. Am J Surg. 1997 Dec;174(6):610–613.
Journal cover image

Published In

Am J Surg

DOI

ISSN

0002-9610

Publication Date

December 1997

Volume

174

Issue

6

Start / End Page

610 / 613

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Surgery
  • Retrospective Studies
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatectomy
  • Female