Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.
Publication
, Journal Article
Wu, TS; Lin, DM; Shi, LS; Damu, AG; Kuo, PC; Kuo, YH
Published in: Chemical & pharmaceutical bulletin
August 2003
From the stems of Rubia wallichiana DECNE, thirty-four structurally related compounds were isolated and identified. Three of them, namely rubiawallin-A (1), -B (2), and -C (3), constitute the first report of their occurrence from the natural source. Their structures were determined by comprehensive analyses of their 1D and 2D NMR, and electron impact (EI) mass spectral data. Furthermore, an in vitro screening of cytotoxicity of the isolated compounds was also evaluated. Among the testing compounds, 1-hydroxy-2-hydroxymethyl-3-methoxyanthraquinone (4) demonstrated most effective cytotoxicity towards Hepa-3B and Colo-205 cells.
Duke Scholars
Published In
Chemical & pharmaceutical bulletin
ISSN
0009-2363
Publication Date
August 2003
Volume
51
Issue
8
Start / End Page
948 / 950
Location
japan
Related Subject Headings
- General Chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
- 0306 Physical Chemistry (incl. Structural)
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
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ICMJE
MLA
NLM
Wu, T. S., Lin, D. M., Shi, L. S., Damu, A. G., Kuo, P. C., & Kuo, Y. H. (2003). Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne. Chemical & Pharmaceutical Bulletin, 51(8), 948–950.
Wu, T. S., D. M. Lin, L. S. Shi, A. G. Damu, P. C. Kuo, and Y. H. Kuo. “Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.” Chemical & Pharmaceutical Bulletin 51, no. 8 (August 2003): 948–50.
Wu TS, Lin DM, Shi LS, Damu AG, Kuo PC, Kuo YH. Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne. Chemical & pharmaceutical bulletin. 2003 Aug;51(8):948–50.
Wu, T. S., et al. “Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne.” Chemical & Pharmaceutical Bulletin, vol. 51, no. 8, Aug. 2003, pp. 948–50.
Wu TS, Lin DM, Shi LS, Damu AG, Kuo PC, Kuo YH. Cytotoxic anthraquinones from the stems of Rubia wallichiana Decne. Chemical & pharmaceutical bulletin. 2003 Aug;51(8):948–950.
Published In
Chemical & pharmaceutical bulletin
ISSN
0009-2363
Publication Date
August 2003
Volume
51
Issue
8
Start / End Page
948 / 950
Location
japan
Related Subject Headings
- General Chemistry
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
- 0306 Physical Chemistry (incl. Structural)
- 0304 Medicinal and Biomolecular Chemistry