Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.
Publication
, Journal Article
Kuo, PC; Shi, LS; Damu, AG; Su, CR; Huang, CH; Ke, CH; Wu, JB; Lin, AJ; Bastow, KF; Lee, KH; Wu, TS
Published in: Journal of natural products
October 2003
Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.
Duke Scholars
Published In
Journal of natural products
ISSN
0163-3864
Publication Date
October 2003
Volume
66
Issue
10
Start / End Page
1324 / 1327
Location
united states
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Kuo, P. C., Shi, L. S., Damu, A. G., Su, C. R., Huang, C. H., Ke, C. H., … Wu, T. S. (2003). Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of Natural Products, 66(10), 1324–1327.
Kuo, P. C., L. S. Shi, A. G. Damu, C. R. Su, C. H. Huang, C. H. Ke, J. B. Wu, et al. “Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.” Journal of Natural Products 66, no. 10 (October 2003): 1324–27.
Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, et al. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of natural products. 2003 Oct;66(10):1324–7.
Kuo, P. C., et al. “Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.” Journal of Natural Products, vol. 66, no. 10, Oct. 2003, pp. 1324–27.
Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of natural products. 2003 Oct;66(10):1324–1327.
Published In
Journal of natural products
ISSN
0163-3864
Publication Date
October 2003
Volume
66
Issue
10
Start / End Page
1324 / 1327
Location
united states
Related Subject Headings
- Medicinal & Biomolecular Chemistry
- 4208 Traditional, complementary and integrative medicine
- 11 Medical and Health Sciences
- 06 Biological Sciences
- 03 Chemical Sciences