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The functional recovery of peripheral nerves following defined acute crush injuries.

Publication ,  Journal Article
Chen, LE; Seaber, AV; Glisson, RR; Davies, H; Murrell, GA; Anthony, DC; Urbaniak, JR
Published in: J Orthop Res
September 1992

This study evaluates the effect of crushing load on functional recovery of the sciatic nerve. Male Sprague-Dawley rats were divided into five groups: sham operation, resected sciatic nerve, and 100 g (13 mm Hg/mm2), 500 g (50 mm Hg/mm2), and 15,000 g (1,000 mm Hg/mm2) of sciatic crush load (groups 1-5). In groups 3-5, a 5-mm segment of sciatic nerve was crushed for 10 min using a specially designed crushing device. Motor functional recovery was assessed from hind-limb walking tracks by calculating a sciatic functional index. There was no detectable functional deficit in the group receiving sham operations, while the resected sciatic nerve group exhibited complete dysfunction for the full duration of the experiment. All groups subjected to crush exhibited an initial deficit that gradually recovered to normal by day 14 (100-g crush), day 39 (500-g crush), and day 53 (15,000-g crush). Histological changes were also related to the initial crushing load and the length of the recovery period. Results indicate that the crushing device described is able to administer an adjustable, defined crush injury to the rat sciatic nerve, and that the functional deficit resulting from such an injury can be easily monitored with a sciatic functional index. The rate of recovery of crushed nerves was directly related to the initial load. All crushed nerves recovered in this experiment, even after the application of a 15,000-g load for 10 min.

Duke Scholars

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

September 1992

Volume

10

Issue

5

Start / End Page

657 / 664

Location

United States

Related Subject Headings

  • Sciatic Nerve
  • Rats, Inbred Strains
  • Rats
  • Peripheral Nerves
  • Orthopedics
  • Nerve Crush
  • Male
  • Axons
  • Animals
  • 4207 Sports science and exercise
 

Citation

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Chen, L. E., Seaber, A. V., Glisson, R. R., Davies, H., Murrell, G. A., Anthony, D. C., & Urbaniak, J. R. (1992). The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res, 10(5), 657–664. https://doi.org/10.1002/jor.1100100508
Chen, L. E., A. V. Seaber, R. R. Glisson, H. Davies, G. A. Murrell, D. C. Anthony, and J. R. Urbaniak. “The functional recovery of peripheral nerves following defined acute crush injuries.J Orthop Res 10, no. 5 (September 1992): 657–64. https://doi.org/10.1002/jor.1100100508.
Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GA, Anthony DC, et al. The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res. 1992 Sep;10(5):657–64.
Chen, L. E., et al. “The functional recovery of peripheral nerves following defined acute crush injuries.J Orthop Res, vol. 10, no. 5, Sept. 1992, pp. 657–64. Pubmed, doi:10.1002/jor.1100100508.
Chen LE, Seaber AV, Glisson RR, Davies H, Murrell GA, Anthony DC, Urbaniak JR. The functional recovery of peripheral nerves following defined acute crush injuries. J Orthop Res. 1992 Sep;10(5):657–664.
Journal cover image

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

September 1992

Volume

10

Issue

5

Start / End Page

657 / 664

Location

United States

Related Subject Headings

  • Sciatic Nerve
  • Rats, Inbred Strains
  • Rats
  • Peripheral Nerves
  • Orthopedics
  • Nerve Crush
  • Male
  • Axons
  • Animals
  • 4207 Sports science and exercise