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Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Publication ,  Journal Article
Lal, A; Glazer, CA; Martinson, HM; Friedman, HS; Archer, GE; Sampson, JH; Riggins, GJ
Published in: Cancer Res
June 15, 2002

The gene most commonly altered in human glioblastomas is the epidermalgrowth factor receptor (EGFR). We profiled transcripts induced by mutantEGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively down-regulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

June 15, 2002

Volume

62

Issue

12

Start / End Page

3335 / 3339

Location

United States

Related Subject Headings

  • Up-Regulation
  • Tyrphostins
  • Tumor Cells, Cultured
  • Transfection
  • Serine Endopeptidases
  • Reverse Transcriptase Polymerase Chain Reaction
  • Quinazolines
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mice, Nude
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lal, A., Glazer, C. A., Martinson, H. M., Friedman, H. S., Archer, G. E., Sampson, J. H., & Riggins, G. J. (2002). Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res, 62(12), 3335–3339.
Lal, Anita, Chad A. Glazer, Holly M. Martinson, Henry S. Friedman, Gary E. Archer, John H. Sampson, and Gregory J. Riggins. “Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.Cancer Res 62, no. 12 (June 15, 2002): 3335–39.
Lal A, Glazer CA, Martinson HM, Friedman HS, Archer GE, Sampson JH, et al. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res. 2002 Jun 15;62(12):3335–9.
Lal, Anita, et al. “Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.Cancer Res, vol. 62, no. 12, June 2002, pp. 3335–39.
Lal A, Glazer CA, Martinson HM, Friedman HS, Archer GE, Sampson JH, Riggins GJ. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res. 2002 Jun 15;62(12):3335–3339.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

June 15, 2002

Volume

62

Issue

12

Start / End Page

3335 / 3339

Location

United States

Related Subject Headings

  • Up-Regulation
  • Tyrphostins
  • Tumor Cells, Cultured
  • Transfection
  • Serine Endopeptidases
  • Reverse Transcriptase Polymerase Chain Reaction
  • Quinazolines
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Mice, Nude