Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies.
Publication
, Journal Article
Lee, SW; Sullenger, BA
Published in: Nat Biotechnol
January 1997
The muscular weakness and fatigability associated with myasthenia gravis are engendered by autoantibodies directed against acetylcholine receptors on muscle cells at neuromuscular junctions. The pathogenic consequences of this immune response can potentially be modulated by molecules that bind such autoantibodies and block their interaction with these receptors. We report the isolation of a small nuclease-resistant RNA molecule that binds both a rat monoclonal antibody that recognizes the main immunogenic region on the acetylcholine receptor, and autoantibodies from patients with myasthenia gravis. Moreover, this RNA can act as a decoy and protect acetylcholine receptors on human cells from the effects of these antibodies.
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Published In
Nat Biotechnol
DOI
ISSN
1087-0156
Publication Date
January 1997
Volume
15
Issue
1
Start / End Page
41 / 45
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Substrate Specificity
- Ribonucleases
- Rhabdomyosarcoma
- Receptors, Cholinergic
- Rats
- RNA
- Myasthenia Gravis
- Molecular Sequence Data
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, S. W., & Sullenger, B. A. (1997). Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nat Biotechnol, 15(1), 41–45. https://doi.org/10.1038/nbt0197-41
Lee, S. W., and B. A. Sullenger. “Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies.” Nat Biotechnol 15, no. 1 (January 1997): 41–45. https://doi.org/10.1038/nbt0197-41.
Lee SW, Sullenger BA. Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nat Biotechnol. 1997 Jan;15(1):41–5.
Lee, S. W., and B. A. Sullenger. “Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies.” Nat Biotechnol, vol. 15, no. 1, Jan. 1997, pp. 41–45. Pubmed, doi:10.1038/nbt0197-41.
Lee SW, Sullenger BA. Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies. Nat Biotechnol. 1997 Jan;15(1):41–45.
Published In
Nat Biotechnol
DOI
ISSN
1087-0156
Publication Date
January 1997
Volume
15
Issue
1
Start / End Page
41 / 45
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Substrate Specificity
- Ribonucleases
- Rhabdomyosarcoma
- Receptors, Cholinergic
- Rats
- RNA
- Myasthenia Gravis
- Molecular Sequence Data
- Humans