Skip to main content
Journal cover image

Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma.

Publication ,  Journal Article
Gomella, LG; Ehya, H; Steinberg, SM; Rupp, M; Merino, M; Robertson, C; Linehan, WM
Published in: J Surg Oncol
August 1993

Adoptive immunotherapy using interleukin-2 (IL-2) based therapy can result in marked tumor regression in some patients with metastatic renal cell carcinoma. DNA flow cytometry has not been previously studied as a predictor of outcome of this therapy. Archival paraffin embedded tumors were studied in 23 IL-2 treated patients with metastatic renal cell carcinoma. Eleven patients were complete responders (CR) and 12 were nonresponders (NR). In the CR group, 4/11 (40%) were diploid and 7/11 (60%) were aneuploid. In the NR group, 9/12 (75%) were diploid and 3/12 (25%) were aneuploid. Although there was a trend that patients with an aneuploid DNA pattern were more likely to undergo a complete response, ploidy pattern alone was not significantly predictive of response (p2 = 0.10, Fischer's exact test). When combining ploidy pattern with other variables that were predictive for complete response, such as good performance status and a higher pretreatment weight, prediction of complete response was not improved by including ploidy. This preliminary report suggests that DNA ploidy does not appear to provide any additional information concerning responsiveness to IL-2 based immunotherapy beyond that obtained by performance status and pretreatment weight in this patient population.

Duke Scholars

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

August 1993

Volume

53

Issue

4

Start / End Page

252 / 255

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Ploidies
  • Oncology & Carcinogenesis
  • Lymphocytes, Tumor-Infiltrating
  • Killer Cells, Lymphokine-Activated
  • Kidney Neoplasms
  • Interleukin-2
  • Humans
  • Flow Cytometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gomella, L. G., Ehya, H., Steinberg, S. M., Rupp, M., Merino, M., Robertson, C., & Linehan, W. M. (1993). Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma. J Surg Oncol, 53(4), 252–255. https://doi.org/10.1002/jso.2930530413
Gomella, L. G., H. Ehya, S. M. Steinberg, M. Rupp, M. Merino, C. Robertson, and W. M. Linehan. “Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma.J Surg Oncol 53, no. 4 (August 1993): 252–55. https://doi.org/10.1002/jso.2930530413.
Gomella LG, Ehya H, Steinberg SM, Rupp M, Merino M, Robertson C, et al. Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma. J Surg Oncol. 1993 Aug;53(4):252–5.
Gomella, L. G., et al. “Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma.J Surg Oncol, vol. 53, no. 4, Aug. 1993, pp. 252–55. Pubmed, doi:10.1002/jso.2930530413.
Gomella LG, Ehya H, Steinberg SM, Rupp M, Merino M, Robertson C, Linehan WM. Flow cytometric DNA analysis of interleukin-2 responsive renal cell carcinoma. J Surg Oncol. 1993 Aug;53(4):252–255.
Journal cover image

Published In

J Surg Oncol

DOI

ISSN

0022-4790

Publication Date

August 1993

Volume

53

Issue

4

Start / End Page

252 / 255

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Predictive Value of Tests
  • Ploidies
  • Oncology & Carcinogenesis
  • Lymphocytes, Tumor-Infiltrating
  • Killer Cells, Lymphokine-Activated
  • Kidney Neoplasms
  • Interleukin-2
  • Humans
  • Flow Cytometry