Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7.
Publication
, Journal Article
Speer, MC; Vance, JM; Grubber, JM; Lennon Graham, F; Stajich, JM; Viles, KD; Rogala, A; McMichael, R; Chutkow, J; Goldsmith, C; Tim, RW ...
Published in: Am J Hum Genet
February 1999
We report the identification of a new locus for autosomal dominant limb-girdle muscular dystrophy (LGMD1) on 7q. Two of five families (1047 and 1701) demonstrate evidence in favor of linkage to this region. The maximum two-point LOD score for family 1047 was 3.76 for D7S427, and that for family 1701 was 2.63 for D7S3058. Flanking markers place the LGMD1 locus between D7S2423 and D7S427, with multipoint analysis slightly favoring the 9-cM interval spanned by D7S2546 and D7S2423. Three of five families appear to be unlinked to this new locus on chromosome 7, thus establishing further heterogeneity within the LGMD1 diagnostic classification.
Duke Scholars
Published In
Am J Hum Genet
DOI
ISSN
0002-9297
Publication Date
February 1999
Volume
64
Issue
2
Start / End Page
556 / 562
Location
United States
Related Subject Headings
- Pedigree
- Muscular Dystrophies
- Male
- Humans
- Genetics & Heredity
- Genetic Testing
- Genes, Dominant
- Female
- Chromosomes, Human, Pair 7
- Chromosome Mapping
Citation
APA
Chicago
ICMJE
MLA
NLM
Speer, M. C., Vance, J. M., Grubber, J. M., Lennon Graham, F., Stajich, J. M., Viles, K. D., … Pericak-Vance, M. A. (1999). Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7. Am J Hum Genet, 64(2), 556–562. https://doi.org/10.1086/302252
Speer, M. C., J. M. Vance, J. M. Grubber, F. Lennon Graham, J. M. Stajich, K. D. Viles, A. Rogala, et al. “Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7.” Am J Hum Genet 64, no. 2 (February 1999): 556–62. https://doi.org/10.1086/302252.
Speer MC, Vance JM, Grubber JM, Lennon Graham F, Stajich JM, Viles KD, et al. Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7. Am J Hum Genet. 1999 Feb;64(2):556–62.
Speer, M. C., et al. “Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7.” Am J Hum Genet, vol. 64, no. 2, Feb. 1999, pp. 556–62. Pubmed, doi:10.1086/302252.
Speer MC, Vance JM, Grubber JM, Lennon Graham F, Stajich JM, Viles KD, Rogala A, McMichael R, Chutkow J, Goldsmith C, Tim RW, Pericak-Vance MA. Identification of a new autosomal dominant limb-girdle muscular dystrophy locus on chromosome 7. Am J Hum Genet. 1999 Feb;64(2):556–562.
Published In
Am J Hum Genet
DOI
ISSN
0002-9297
Publication Date
February 1999
Volume
64
Issue
2
Start / End Page
556 / 562
Location
United States
Related Subject Headings
- Pedigree
- Muscular Dystrophies
- Male
- Humans
- Genetics & Heredity
- Genetic Testing
- Genes, Dominant
- Female
- Chromosomes, Human, Pair 7
- Chromosome Mapping