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Monitor peptide binding sites are expressed in the rat liver and small intestine.

Publication ,  Journal Article
McVey, DC; Romac, JM; Clay, WC; Kost, TA; Liddle, RA; Vigna, SR
Published in: Peptides
1999

125I-monitor peptide binding was performed using frozen sections of the rat liver and gut and visualized using autoradiography. Saturable binding was observed in unidentified single cells in the liver and in the mucosa of the small intestine. Epidermal growth factor (EGF) and GTPgammaS did not inhibit 125I-monitor peptide binding indicating that the binding sites are not EGF receptors or G protein-coupled receptors. The liver binding site exhibited an affinity 3.7-4.4-fold higher than those in the small intestine. It has been established that intraluminal monitor peptide releases cholecystokinin from the small intestine. The present results indicate that monitor peptide may also have liver associated functions.

Duke Scholars

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

1999

Volume

20

Issue

4

Start / End Page

457 / 464

Location

United States

Related Subject Headings

  • Trypsin Inhibitor, Kazal Pancreatic
  • Receptors, Peptide
  • Rats
  • Protein Binding
  • Pancreatic Hormones
  • Liver
  • Iodine Radioisotopes
  • Intestine, Small
  • Intercellular Signaling Peptides and Proteins
  • Guanosine 5'-O-(3-Thiotriphosphate)
 

Citation

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MLA
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McVey, D. C., Romac, J. M., Clay, W. C., Kost, T. A., Liddle, R. A., & Vigna, S. R. (1999). Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides, 20(4), 457–464. https://doi.org/10.1016/s0196-9781(99)00026-1
McVey, D. C., J. M. Romac, W. C. Clay, T. A. Kost, R. A. Liddle, and S. R. Vigna. “Monitor peptide binding sites are expressed in the rat liver and small intestine.Peptides 20, no. 4 (1999): 457–64. https://doi.org/10.1016/s0196-9781(99)00026-1.
McVey DC, Romac JM, Clay WC, Kost TA, Liddle RA, Vigna SR. Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides. 1999;20(4):457–64.
McVey, D. C., et al. “Monitor peptide binding sites are expressed in the rat liver and small intestine.Peptides, vol. 20, no. 4, 1999, pp. 457–64. Pubmed, doi:10.1016/s0196-9781(99)00026-1.
McVey DC, Romac JM, Clay WC, Kost TA, Liddle RA, Vigna SR. Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides. 1999;20(4):457–464.
Journal cover image

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

1999

Volume

20

Issue

4

Start / End Page

457 / 464

Location

United States

Related Subject Headings

  • Trypsin Inhibitor, Kazal Pancreatic
  • Receptors, Peptide
  • Rats
  • Protein Binding
  • Pancreatic Hormones
  • Liver
  • Iodine Radioisotopes
  • Intestine, Small
  • Intercellular Signaling Peptides and Proteins
  • Guanosine 5'-O-(3-Thiotriphosphate)