Monitor peptide binding sites are expressed in the rat liver and small intestine.
Publication
, Journal Article
McVey, DC; Romac, JM; Clay, WC; Kost, TA; Liddle, RA; Vigna, SR
Published in: Peptides
1999
125I-monitor peptide binding was performed using frozen sections of the rat liver and gut and visualized using autoradiography. Saturable binding was observed in unidentified single cells in the liver and in the mucosa of the small intestine. Epidermal growth factor (EGF) and GTPgammaS did not inhibit 125I-monitor peptide binding indicating that the binding sites are not EGF receptors or G protein-coupled receptors. The liver binding site exhibited an affinity 3.7-4.4-fold higher than those in the small intestine. It has been established that intraluminal monitor peptide releases cholecystokinin from the small intestine. The present results indicate that monitor peptide may also have liver associated functions.
Duke Scholars
Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
1999
Volume
20
Issue
4
Start / End Page
457 / 464
Location
United States
Related Subject Headings
- Trypsin Inhibitor, Kazal Pancreatic
- Receptors, Peptide
- Rats
- Protein Binding
- Pancreatic Hormones
- Liver
- Iodine Radioisotopes
- Intestine, Small
- Intercellular Signaling Peptides and Proteins
- Guanosine 5'-O-(3-Thiotriphosphate)
Citation
APA
Chicago
ICMJE
MLA
NLM
McVey, D. C., Romac, J. M., Clay, W. C., Kost, T. A., Liddle, R. A., & Vigna, S. R. (1999). Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides, 20(4), 457–464. https://doi.org/10.1016/s0196-9781(99)00026-1
McVey, D. C., J. M. Romac, W. C. Clay, T. A. Kost, R. A. Liddle, and S. R. Vigna. “Monitor peptide binding sites are expressed in the rat liver and small intestine.” Peptides 20, no. 4 (1999): 457–64. https://doi.org/10.1016/s0196-9781(99)00026-1.
McVey DC, Romac JM, Clay WC, Kost TA, Liddle RA, Vigna SR. Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides. 1999;20(4):457–64.
McVey, D. C., et al. “Monitor peptide binding sites are expressed in the rat liver and small intestine.” Peptides, vol. 20, no. 4, 1999, pp. 457–64. Pubmed, doi:10.1016/s0196-9781(99)00026-1.
McVey DC, Romac JM, Clay WC, Kost TA, Liddle RA, Vigna SR. Monitor peptide binding sites are expressed in the rat liver and small intestine. Peptides. 1999;20(4):457–464.
Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
1999
Volume
20
Issue
4
Start / End Page
457 / 464
Location
United States
Related Subject Headings
- Trypsin Inhibitor, Kazal Pancreatic
- Receptors, Peptide
- Rats
- Protein Binding
- Pancreatic Hormones
- Liver
- Iodine Radioisotopes
- Intestine, Small
- Intercellular Signaling Peptides and Proteins
- Guanosine 5'-O-(3-Thiotriphosphate)