Scholars@Duke

Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

Publication ,  Journal Article
Taylor, DA; Atkins, BZ; Hungspreugs, P; Jones, TR; Reedy, MC; Hutcheson, KA; Glower, DD; Kraus, WE
Published in: Nat Med
August 1998
Published version (DOI) Link to item

The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.

Duke Scholars

William Erle Kraus
Author William Erle Kraus Medicine, Cardiology
Donald D. Glower Jr.
Author Donald D. Glower Jr. Surgery, Cardiovascular and Thoracic Surgery
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Med

DOI

10.1038/nm0898-929

ISSN

1078-8956

Publication Date

August 1998

Volume

4

Issue

8

Start / End Page

929 / 933

Location

United States

Related Subject Headings

  • Regeneration
  • Rabbits
  • Myocardium
  • Myocardial Infarction
  • Muscle, Skeletal
  • Microscopy, Electron
  • Immunology
  • Heart
  • Freezing
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Taylor, D. A., Atkins, B. Z., Hungspreugs, P., Jones, T. R., Reedy, M. C., Hutcheson, K. A., … Kraus, W. E. (1998). Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med, 4(8), 929–933. https://doi.org/10.1038/nm0898-929
Taylor, D. A., B. Z. Atkins, P. Hungspreugs, T. R. Jones, M. C. Reedy, K. A. Hutcheson, D. D. Glower, and W. E. Kraus. “Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.” Nat Med 4, no. 8 (August 1998): 929–33. https://doi.org/10.1038/nm0898-929.
Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, et al. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med. 1998 Aug;4(8):929–33.
Taylor, D. A., et al. “Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.” Nat Med, vol. 4, no. 8, Aug. 1998, pp. 929–33. Pubmed, doi:10.1038/nm0898-929.
Taylor DA, Atkins BZ, Hungspreugs P, Jones TR, Reedy MC, Hutcheson KA, Glower DD, Kraus WE. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation. Nat Med. 1998 Aug;4(8):929–933.

Published In

Nat Med

DOI

10.1038/nm0898-929

ISSN

1078-8956

Publication Date

August 1998

Volume

4

Issue

8

Start / End Page

929 / 933

Location

United States

Related Subject Headings

  • Regeneration
  • Rabbits
  • Myocardium
  • Myocardial Infarction
  • Muscle, Skeletal
  • Microscopy, Electron
  • Immunology
  • Heart
  • Freezing
  • Cells, Cultured