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Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.

Publication ,  Journal Article
Lilley, ER; Rosenberg, MC; Elion, GB; Colvin, OM; Bigner, DD; Friedman, HS
Published in: Cancer Res
January 15, 1990

Based on previous work demonstrating the activity of cyclophosphamide and melphalan in a series of human medulloblastoma and rhabdomyosarcoma cell lines and transplantable xenografts, investigations were conducted to define the effects of combining cyclophosphamide or melphalan with VP-16. These studies demonstrated a synergistic interaction between cyclophosphamide and VP-16 and melphalan and VP-16 in the treatment of the human rhabdomyosarcoma cell line TE-671 growing in athymic mice. The combination of cyclophosphamide or melphalan with VP-16 may warrant consideration as a therapeutic strategy for solid tumors sensitive to bifunctional alkylating agents.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

January 15, 1990

Volume

50

Issue

2

Start / End Page

284 / 287

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Rhabdomyosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Melphalan
  • Male
  • Female
  • Etoposide
 

Citation

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MLA
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Lilley, E. R., Rosenberg, M. C., Elion, G. B., Colvin, O. M., Bigner, D. D., & Friedman, H. S. (1990). Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res, 50(2), 284–287.
Lilley, E. R., M. C. Rosenberg, G. B. Elion, O. M. Colvin, D. D. Bigner, and H. S. Friedman. “Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.Cancer Res 50, no. 2 (January 15, 1990): 284–87.
Lilley ER, Rosenberg MC, Elion GB, Colvin OM, Bigner DD, Friedman HS. Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res. 1990 Jan 15;50(2):284–7.
Lilley, E. R., et al. “Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.Cancer Res, vol. 50, no. 2, Jan. 1990, pp. 284–87.
Lilley ER, Rosenberg MC, Elion GB, Colvin OM, Bigner DD, Friedman HS. Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res. 1990 Jan 15;50(2):284–287.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

January 15, 1990

Volume

50

Issue

2

Start / End Page

284 / 287

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Rhabdomyosarcoma
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Melphalan
  • Male
  • Female
  • Etoposide