Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.
Publication
, Journal Article
Lilley, ER; Rosenberg, MC; Elion, GB; Colvin, OM; Bigner, DD; Friedman, HS
Published in: Cancer Res
January 15, 1990
Based on previous work demonstrating the activity of cyclophosphamide and melphalan in a series of human medulloblastoma and rhabdomyosarcoma cell lines and transplantable xenografts, investigations were conducted to define the effects of combining cyclophosphamide or melphalan with VP-16. These studies demonstrated a synergistic interaction between cyclophosphamide and VP-16 and melphalan and VP-16 in the treatment of the human rhabdomyosarcoma cell line TE-671 growing in athymic mice. The combination of cyclophosphamide or melphalan with VP-16 may warrant consideration as a therapeutic strategy for solid tumors sensitive to bifunctional alkylating agents.
Duke Scholars
Published In
Cancer Res
ISSN
0008-5472
Publication Date
January 15, 1990
Volume
50
Issue
2
Start / End Page
284 / 287
Location
United States
Related Subject Headings
- Transplantation, Heterologous
- Rhabdomyosarcoma
- Oncology & Carcinogenesis
- Neoplasm Transplantation
- Mice, Inbred BALB C
- Mice
- Melphalan
- Male
- Female
- Etoposide
Citation
APA
Chicago
ICMJE
MLA
NLM
Lilley, E. R., Rosenberg, M. C., Elion, G. B., Colvin, O. M., Bigner, D. D., & Friedman, H. S. (1990). Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res, 50(2), 284–287.
Lilley, E. R., M. C. Rosenberg, G. B. Elion, O. M. Colvin, D. D. Bigner, and H. S. Friedman. “Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.” Cancer Res 50, no. 2 (January 15, 1990): 284–87.
Lilley ER, Rosenberg MC, Elion GB, Colvin OM, Bigner DD, Friedman HS. Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res. 1990 Jan 15;50(2):284–7.
Lilley, E. R., et al. “Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.” Cancer Res, vol. 50, no. 2, Jan. 1990, pp. 284–87.
Lilley ER, Rosenberg MC, Elion GB, Colvin OM, Bigner DD, Friedman HS. Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft. Cancer Res. 1990 Jan 15;50(2):284–287.
Published In
Cancer Res
ISSN
0008-5472
Publication Date
January 15, 1990
Volume
50
Issue
2
Start / End Page
284 / 287
Location
United States
Related Subject Headings
- Transplantation, Heterologous
- Rhabdomyosarcoma
- Oncology & Carcinogenesis
- Neoplasm Transplantation
- Mice, Inbred BALB C
- Mice
- Melphalan
- Male
- Female
- Etoposide