Identification of an amplified, highly expressed gene in a human glioma.
Publication
, Journal Article
Kinzler, KW; Bigner, SH; Bigner, DD; Trent, JM; Law, ML; O'Brien, SJ; Wong, AJ; Vogelstein, B
Published in: Science
April 3, 1987
A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Science
DOI
ISSN
0036-8075
Publication Date
April 3, 1987
Volume
236
Issue
4797
Start / End Page
70 / 73
Location
United States
Related Subject Headings
- RNA, Neoplasm
- RNA, Messenger
- Humans
- Glioma
- General Science & Technology
- Gene Expression Regulation
- Gene Amplification
- DNA, Neoplasm
- Cloning, Molecular
- Chromosomes, Human, Pair 12
Citation
APA
Chicago
ICMJE
MLA
NLM
Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O’Brien, S. J., … Vogelstein, B. (1987). Identification of an amplified, highly expressed gene in a human glioma. Science, 236(4797), 70–73. https://doi.org/10.1126/science.3563490
Kinzler, K. W., S. H. Bigner, D. D. Bigner, J. M. Trent, M. L. Law, S. J. O’Brien, A. J. Wong, and B. Vogelstein. “Identification of an amplified, highly expressed gene in a human glioma.” Science 236, no. 4797 (April 3, 1987): 70–73. https://doi.org/10.1126/science.3563490.
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O’Brien SJ, et al. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987 Apr 3;236(4797):70–3.
Kinzler, K. W., et al. “Identification of an amplified, highly expressed gene in a human glioma.” Science, vol. 236, no. 4797, Apr. 1987, pp. 70–73. Pubmed, doi:10.1126/science.3563490.
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O’Brien SJ, Wong AJ, Vogelstein B. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987 Apr 3;236(4797):70–73.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
April 3, 1987
Volume
236
Issue
4797
Start / End Page
70 / 73
Location
United States
Related Subject Headings
- RNA, Neoplasm
- RNA, Messenger
- Humans
- Glioma
- General Science & Technology
- Gene Expression Regulation
- Gene Amplification
- DNA, Neoplasm
- Cloning, Molecular
- Chromosomes, Human, Pair 12