Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).
Publication
, Journal Article
Friedman, HS; Bigner, SH; Bigner, DD
Published in: J Neurooncol
1995
Medulloblastoma, the most common malignancy of childhood, was originally shown to be sensitive to cyclophosphamide in 1981. We have used combined laboratory and clinical investigations to demonstrate the synergy of cyclophosphamide and vincristine in the treatment of this tumor, the therapeutic gain associated with escalation of the dosage of cyclophosphamide, the consequence of and mechanisms underlying resistance of medulloblastoma to cyclophosphamide, the emerging importance of the neuraxis as a site of relapse of medulloblastoma, and newer approaches, including intrathecal 4-hydroperoxycyclophosphamide and busulfan, to treat neuraxis disease. These studies serve as a paradigm for laboratory-clinical translational research.
Duke Scholars
Published In
J Neurooncol
DOI
ISSN
0167-594X
Publication Date
1995
Volume
24
Issue
1
Start / End Page
103 / 108
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Meningitis
- Meningeal Neoplasms
- Medulloblastoma
- Humans
- Drug Resistance, Neoplasm
- Cyclophosphamide
- Clinical Trials as Topic
- Clinical Laboratory Techniques
- Animals
Citation
APA
Chicago
ICMJE
MLA
NLM
Friedman, H. S., Bigner, S. H., & Bigner, D. D. (1995). Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again). J Neurooncol, 24(1), 103–108. https://doi.org/10.1007/BF01052667
Friedman, H. S., S. H. Bigner, and D. D. Bigner. “Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).” J Neurooncol 24, no. 1 (1995): 103–8. https://doi.org/10.1007/BF01052667.
Friedman HS, Bigner SH, Bigner DD. Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again). J Neurooncol. 1995;24(1):103–8.
Friedman, H. S., et al. “Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).” J Neurooncol, vol. 24, no. 1, 1995, pp. 103–08. Pubmed, doi:10.1007/BF01052667.
Friedman HS, Bigner SH, Bigner DD. Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again). J Neurooncol. 1995;24(1):103–108.
Published In
J Neurooncol
DOI
ISSN
0167-594X
Publication Date
1995
Volume
24
Issue
1
Start / End Page
103 / 108
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Meningitis
- Meningeal Neoplasms
- Medulloblastoma
- Humans
- Drug Resistance, Neoplasm
- Cyclophosphamide
- Clinical Trials as Topic
- Clinical Laboratory Techniques
- Animals