Skip to main content
Journal cover image

Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).

Publication ,  Journal Article
Friedman, HS; Bigner, SH; Bigner, DD
Published in: J Neurooncol
1995

Medulloblastoma, the most common malignancy of childhood, was originally shown to be sensitive to cyclophosphamide in 1981. We have used combined laboratory and clinical investigations to demonstrate the synergy of cyclophosphamide and vincristine in the treatment of this tumor, the therapeutic gain associated with escalation of the dosage of cyclophosphamide, the consequence of and mechanisms underlying resistance of medulloblastoma to cyclophosphamide, the emerging importance of the neuraxis as a site of relapse of medulloblastoma, and newer approaches, including intrathecal 4-hydroperoxycyclophosphamide and busulfan, to treat neuraxis disease. These studies serve as a paradigm for laboratory-clinical translational research.

Duke Scholars

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

1995

Volume

24

Issue

1

Start / End Page

103 / 108

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Meningitis
  • Meningeal Neoplasms
  • Medulloblastoma
  • Humans
  • Drug Resistance, Neoplasm
  • Cyclophosphamide
  • Clinical Trials as Topic
  • Clinical Laboratory Techniques
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friedman, H. S., Bigner, S. H., & Bigner, D. D. (1995). Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again). J Neurooncol, 24(1), 103–108. https://doi.org/10.1007/BF01052667
Friedman, H. S., S. H. Bigner, and D. D. Bigner. “Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).J Neurooncol 24, no. 1 (1995): 103–8. https://doi.org/10.1007/BF01052667.
Friedman, H. S., et al. “Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).J Neurooncol, vol. 24, no. 1, 1995, pp. 103–08. Pubmed, doi:10.1007/BF01052667.
Journal cover image

Published In

J Neurooncol

DOI

ISSN

0167-594X

Publication Date

1995

Volume

24

Issue

1

Start / End Page

103 / 108

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Meningitis
  • Meningeal Neoplasms
  • Medulloblastoma
  • Humans
  • Drug Resistance, Neoplasm
  • Cyclophosphamide
  • Clinical Trials as Topic
  • Clinical Laboratory Techniques
  • Animals