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Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.

Publication ,  Journal Article
Friedman, HS; Schold, SC; Varia, M; Bigner, DD
Published in: Cancer Res
July 1983

The human medulloblastoma cell line TE-671 was grown s.c. and intracranially in athymic nude mice. Tumor-bearing animals treated with chemotherapeutic agents or radiation were compared to untreated tumor-bearing controls. Tumors growing s.c. were sensitive to cyclophosphamide and vincristine with growth delays in duplicate trials of 15.8/16.5 and 12.9/15.0 days, respectively. These tumors were minimally responsive to the 2,5-bis(1-aziridinyl-3,6-dioxodiethyl ester of 1,4-cyclohexadiene-1,4-dicarbamic acid (NSC 182986) and cis-diamminedichloroplatinum II and unresponsive to methotrexate, 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido(2,3-d)pyrimidine (NSC 351521), 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962), and procarbazine. Radiation therapy with 2500 or 1500 rads as a single fraction produced a marked response, with growth delays of 39.5 and 21.1 days, respectively. Cyclophosphamide produced a significant (p less than 0.0005) increase in the median survival of mice with intracranial tumors. Vincristine produced a minimal increase in the median survival while no response was seen to the 2,5-bis(1-aziridinyl-3,6-dioxodiethyl ester of (1,4-cyclohexadiene-1,4-dicarbamic acid at the dose level and schedule tested. This model system will allow further analysis of the therapeutic sensitivity of human medulloblastoma to other agents or combined-modality regimens.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1983

Volume

43

Issue

7

Start / End Page

3088 / 3093

Location

United States

Related Subject Headings

  • Vincristine
  • Time Factors
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Medulloblastoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Friedman, H. S., Schold, S. C., Varia, M., & Bigner, D. D. (1983). Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. Cancer Res, 43(7), 3088–3093.
Friedman, H. S., S. C. Schold, M. Varia, and D. D. Bigner. “Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.Cancer Res 43, no. 7 (July 1983): 3088–93.
Friedman HS, Schold SC, Varia M, Bigner DD. Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. Cancer Res. 1983 Jul;43(7):3088–93.
Friedman, H. S., et al. “Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice.Cancer Res, vol. 43, no. 7, July 1983, pp. 3088–93.
Friedman HS, Schold SC, Varia M, Bigner DD. Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. Cancer Res. 1983 Jul;43(7):3088–3093.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1983

Volume

43

Issue

7

Start / End Page

3088 / 3093

Location

United States

Related Subject Headings

  • Vincristine
  • Time Factors
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Medulloblastoma