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Structural chromosomal abnormalities in human medulloblastoma.

Publication ,  Journal Article
Bigner, SH; Mark, J; Friedman, HS; Biegel, JA; Bigner, DD
Published in: Cancer Genet Cytogenet
January 1988

Seven human medulloblastomas (four primary cerebellar, three recurrent or metastatic) were karyotyped in direct preparation and/or short-term or early culture. One tumor had a 46,XX stem line. Four of the six remaining tumors contained one or more i(17q), and three of these six tumors had deletions of extra copies of chromosome #1, resulting in trisomy of 1p, 1q, or both. Two tumors had near-centromeric breaks of chromosome #3, two tumors contained unbalanced translocations with breakpoints at 20q13, and two tumors contained double minutes. These findings suggest that the primary karyotypic deviations of human medulloblastomas are gains of whole chromosomes, which are then either deleted or involved in unbalanced translocations, resulting in partial trisomies.

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Published In

Cancer Genet Cytogenet

DOI

ISSN

0165-4608

Publication Date

January 1988

Volume

30

Issue

1

Start / End Page

91 / 101

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Medulloblastoma
  • Male
  • Karyotyping
  • Humans
  • Genetic Markers
  • Female
  • Chromosome Banding
  • Chromosome Aberrations
  • Child, Preschool
 

Citation

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Chicago
ICMJE
MLA
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Bigner, S. H., Mark, J., Friedman, H. S., Biegel, J. A., & Bigner, D. D. (1988). Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet Cytogenet, 30(1), 91–101. https://doi.org/10.1016/0165-4608(88)90096-9
Bigner, S. H., J. Mark, H. S. Friedman, J. A. Biegel, and D. D. Bigner. “Structural chromosomal abnormalities in human medulloblastoma.Cancer Genet Cytogenet 30, no. 1 (January 1988): 91–101. https://doi.org/10.1016/0165-4608(88)90096-9.
Bigner SH, Mark J, Friedman HS, Biegel JA, Bigner DD. Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet Cytogenet. 1988 Jan;30(1):91–101.
Bigner, S. H., et al. “Structural chromosomal abnormalities in human medulloblastoma.Cancer Genet Cytogenet, vol. 30, no. 1, Jan. 1988, pp. 91–101. Pubmed, doi:10.1016/0165-4608(88)90096-9.
Bigner SH, Mark J, Friedman HS, Biegel JA, Bigner DD. Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet Cytogenet. 1988 Jan;30(1):91–101.
Journal cover image

Published In

Cancer Genet Cytogenet

DOI

ISSN

0165-4608

Publication Date

January 1988

Volume

30

Issue

1

Start / End Page

91 / 101

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Medulloblastoma
  • Male
  • Karyotyping
  • Humans
  • Genetic Markers
  • Female
  • Chromosome Banding
  • Chromosome Aberrations
  • Child, Preschool