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Infrequent p53 gene mutations in medulloblastomas.

Publication ,  Journal Article
Saylors, RL; Sidransky, D; Friedman, HS; Bigner, SH; Bigner, DD; Vogelstein, B; Brodeur, GM
Published in: Cancer Res
September 1, 1991

Cytogenetic and molecular studies of medulloblastomas have demonstrated frequent loss of sequences from the short arm of chromosome 17, possibly implicating loss or inactivation of the p53 tumor suppressor gene. We amplified exons 5 through 8 of the p53 gene by the polymerase chain reaction technique. These segments, which encompass the regions usually mutated in human tumors, were sequenced to search for p53 mutations in 12 medulloblastoma tumors, 8 xenografts, and 3 permanent cell lines. Mutation of the p53 gene was found in only 1 of 3 cell lines tested and in none of the xenografts or primary tumors studied. Our results suggest that p53 is mutated in an unusual way or that a second tumor suppressor gene on the short arm of chromosome 17 is involved in the pathogenesis of medulloblastoma.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

September 1, 1991

Volume

51

Issue

17

Start / End Page

4721 / 4723

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Mutation
  • Medulloblastoma
  • Humans
  • Genes, p53
  • Chromosomes, Human, Pair 17
  • Cerebellar Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Saylors, R. L., Sidransky, D., Friedman, H. S., Bigner, S. H., Bigner, D. D., Vogelstein, B., & Brodeur, G. M. (1991). Infrequent p53 gene mutations in medulloblastomas. Cancer Res, 51(17), 4721–4723.
Saylors, R. L., D. Sidransky, H. S. Friedman, S. H. Bigner, D. D. Bigner, B. Vogelstein, and G. M. Brodeur. “Infrequent p53 gene mutations in medulloblastomas.Cancer Res 51, no. 17 (September 1, 1991): 4721–23.
Saylors RL, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B, et al. Infrequent p53 gene mutations in medulloblastomas. Cancer Res. 1991 Sep 1;51(17):4721–3.
Saylors, R. L., et al. “Infrequent p53 gene mutations in medulloblastomas.Cancer Res, vol. 51, no. 17, Sept. 1991, pp. 4721–23.
Saylors RL, Sidransky D, Friedman HS, Bigner SH, Bigner DD, Vogelstein B, Brodeur GM. Infrequent p53 gene mutations in medulloblastomas. Cancer Res. 1991 Sep 1;51(17):4721–4723.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

September 1, 1991

Volume

51

Issue

17

Start / End Page

4721 / 4723

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Oncology & Carcinogenesis
  • Mutation
  • Medulloblastoma
  • Humans
  • Genes, p53
  • Chromosomes, Human, Pair 17
  • Cerebellar Neoplasms
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology