In vivo measurement of regional brain tissue pH using positron emission tomography.
Publication
, Journal Article
Rottenberg, DA; Ginos, JZ; Kearfott, KJ; Junck, L; Bigner, DD
Published in: Ann Neurol
1984
Carbon-11-labeled dimethyloxazolidinedione ([11C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain-blood equilibration was achieved or could be accurately predicted from dynamic PET and 11C blood data. Knowledge of regional brain-blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [11C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [14C]DMO concentrations in rat brain slices.
Duke Scholars
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
1984
Volume
15 Suppl
Start / End Page
S98 / 102
Location
United States
Related Subject Headings
- Tomography, Emission-Computed
- Neurology & Neurosurgery
- Hydrogen-Ion Concentration
- Humans
- Dimethadione
- Brain Neoplasms
- Brain Chemistry
- Brain
- 3209 Neurosciences
- 3202 Clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Rottenberg, D. A., Ginos, J. Z., Kearfott, K. J., Junck, L., & Bigner, D. D. (1984). In vivo measurement of regional brain tissue pH using positron emission tomography. Ann Neurol, 15 Suppl, S98-102. https://doi.org/10.1002/ana.410150718
Rottenberg, D. A., J. Z. Ginos, K. J. Kearfott, L. Junck, and D. D. Bigner. “In vivo measurement of regional brain tissue pH using positron emission tomography.” Ann Neurol 15 Suppl (1984): S98-102. https://doi.org/10.1002/ana.410150718.
Rottenberg DA, Ginos JZ, Kearfott KJ, Junck L, Bigner DD. In vivo measurement of regional brain tissue pH using positron emission tomography. Ann Neurol. 1984;15 Suppl:S98-102.
Rottenberg, D. A., et al. “In vivo measurement of regional brain tissue pH using positron emission tomography.” Ann Neurol, vol. 15 Suppl, 1984, pp. S98-102. Pubmed, doi:10.1002/ana.410150718.
Rottenberg DA, Ginos JZ, Kearfott KJ, Junck L, Bigner DD. In vivo measurement of regional brain tissue pH using positron emission tomography. Ann Neurol. 1984;15 Suppl:S98-102.
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
1984
Volume
15 Suppl
Start / End Page
S98 / 102
Location
United States
Related Subject Headings
- Tomography, Emission-Computed
- Neurology & Neurosurgery
- Hydrogen-Ion Concentration
- Humans
- Dimethadione
- Brain Neoplasms
- Brain Chemistry
- Brain
- 3209 Neurosciences
- 3202 Clinical sciences