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Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.

Publication ,  Journal Article
Månsson, JE; Fredman, P; Bigner, DD; Molin, K; Rosengren, B; Friedman, HS; Svennerholm, L
Published in: FEBS Lett
May 26, 1986

The major mono- and disialogangliosides of the extensively characterized established human glioma line D54MG were isolated and purified from subcutaneous solid xenografts grown in athymic (nu/nu) mice. Structural determination showed that they belonged to the lactotetraosylceramide series. The sialyllactotetraosylceramide contained 90% N-glycolyl- and 10% N-acetylneuraminic acid linked in an alpha 2-3 linkage (IV3NeuGc-LcOse4Cer, IV3NeuAc-LcOse4Cer). The disialogangliosides had a previously undescribed type of structure with sialic acids linked to the terminal galactose in an alpha 2-3 linkage and to N-acetylglucosamine in an alpha 2-6 linkage. Not only did species with NeuAc or NeuGc occur, but also species with mixtures of the two sialic acids, e.g. NeuAc and NeuGc. The schematic structures of the new disialogangliosides are (Formula:see text).

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Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

May 26, 1986

Volume

201

Issue

1

Start / End Page

109 / 113

Location

England

Related Subject Headings

  • Transplantation, Heterologous
  • Sphingosine
  • Sialic Acids
  • Neuraminic Acids
  • Neoplasm Transplantation
  • N-Acetylneuraminic Acid
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Mass Spectrometry
 

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Månsson, J. E., Fredman, P., Bigner, D. D., Molin, K., Rosengren, B., Friedman, H. S., & Svennerholm, L. (1986). Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. FEBS Lett, 201(1), 109–113. https://doi.org/10.1016/0014-5793(86)80580-4
Månsson, J. E., P. Fredman, D. D. Bigner, K. Molin, B. Rosengren, H. S. Friedman, and L. Svennerholm. “Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.FEBS Lett 201, no. 1 (May 26, 1986): 109–13. https://doi.org/10.1016/0014-5793(86)80580-4.
Månsson JE, Fredman P, Bigner DD, Molin K, Rosengren B, Friedman HS, et al. Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. FEBS Lett. 1986 May 26;201(1):109–13.
Månsson, J. E., et al. “Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line.FEBS Lett, vol. 201, no. 1, May 1986, pp. 109–13. Pubmed, doi:10.1016/0014-5793(86)80580-4.
Månsson JE, Fredman P, Bigner DD, Molin K, Rosengren B, Friedman HS, Svennerholm L. Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. FEBS Lett. 1986 May 26;201(1):109–113.
Journal cover image

Published In

FEBS Lett

DOI

ISSN

0014-5793

Publication Date

May 26, 1986

Volume

201

Issue

1

Start / End Page

109 / 113

Location

England

Related Subject Headings

  • Transplantation, Heterologous
  • Sphingosine
  • Sialic Acids
  • Neuraminic Acids
  • Neoplasm Transplantation
  • N-Acetylneuraminic Acid
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Mass Spectrometry