Essential role of LAT in T cell development.
Publication
, Journal Article
Zhang, W; Sommers, CL; Burshtyn, DN; Stebbins, CC; DeJarnette, JB; Trible, RP; Grinberg, A; Tsay, HC; Jacobs, HM; Kessler, CM; Long, EO ...
Published in: Immunity
March 1999
The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules. The central role of this molecule in TCR-mediated signaling has been demonstrated by experiments in a LAT-deficient cell line. To probe the role of LAT in T cell development, the LAT gene was disrupted by targeting. LAT-deficient mice appeared healthy. Flow cytometric analysis revealed normal B cell populations but the absence of any mature peripheral T cells. Intrathymic development was blocked within the CD4- CD8- stage. No gross abnormality of NK or platelet function was observed. LAT is thus critical to both T cell activation and development.
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Published In
Immunity
DOI
ISSN
1074-7613
Publication Date
March 1999
Volume
10
Issue
3
Start / End Page
323 / 332
Location
United States
Related Subject Headings
- T-Lymphocyte Subsets
- Signal Transduction
- Receptors, Antigen, T-Cell, gamma-delta
- Receptors, Antigen, T-Cell
- Phosphoproteins
- Mice, Knockout
- Mice, Inbred Strains
- Mice
- Membrane Proteins
- Killer Cells, Natural
Citation
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Chicago
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Zhang, W., Sommers, C. L., Burshtyn, D. N., Stebbins, C. C., DeJarnette, J. B., Trible, R. P., … Samelson, L. E. (1999). Essential role of LAT in T cell development. Immunity, 10(3), 323–332. https://doi.org/10.1016/s1074-7613(00)80032-1
Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, et al. “Essential role of LAT in T cell development.” Immunity 10, no. 3 (March 1999): 323–32. https://doi.org/10.1016/s1074-7613(00)80032-1.
Zhang W, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, et al. Essential role of LAT in T cell development. Immunity. 1999 Mar;10(3):323–32.
Zhang, W., et al. “Essential role of LAT in T cell development.” Immunity, vol. 10, no. 3, Mar. 1999, pp. 323–32. Pubmed, doi:10.1016/s1074-7613(00)80032-1.
Zhang W, Sommers CL, Burshtyn DN, Stebbins CC, DeJarnette JB, Trible RP, Grinberg A, Tsay HC, Jacobs HM, Kessler CM, Long EO, Love PE, Samelson LE. Essential role of LAT in T cell development. Immunity. 1999 Mar;10(3):323–332.
Published In
Immunity
DOI
ISSN
1074-7613
Publication Date
March 1999
Volume
10
Issue
3
Start / End Page
323 / 332
Location
United States
Related Subject Headings
- T-Lymphocyte Subsets
- Signal Transduction
- Receptors, Antigen, T-Cell, gamma-delta
- Receptors, Antigen, T-Cell
- Phosphoproteins
- Mice, Knockout
- Mice, Inbred Strains
- Mice
- Membrane Proteins
- Killer Cells, Natural