Molecular basis of T cell inactivation by CTLA-4.
Publication
, Journal Article
Lee, KM; Chuang, E; Griffin, M; Khattri, R; Hong, DK; Zhang, W; Straus, D; Samelson, LE; Thompson, CB; Bluestone, JA
Published in: Science
December 18, 1998
CTLA-4, a negative regulator of T cell function, was found to associate with the T cell receptor (TCR) complex zeta chain in primary T cells. The association of TCRzeta with CTLA-4, reconstituted in 293 transfectants, was enhanced by p56(lck)-induced tyrosine phosphorylation. Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRzeta bound to CTLA-4 and abolished the p56(lck)-inducible TCRzeta-CTLA-4 interaction. Thus, CTLA-4 inhibits TCR signal transduction by binding to TCRzeta and inhibiting tyrosine phosphorylation after T cell activation. These findings have broad implications for the negative regulation of T cell function and T cell tolerance.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 18, 1998
Volume
282
Issue
5397
Start / End Page
2263 / 2266
Location
United States
Related Subject Headings
- src Homology Domains
- Transfection
- T-Lymphocytes
- Signal Transduction
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- Recombinant Fusion Proteins
- Receptors, Antigen, T-Cell
- Protein Tyrosine Phosphatases
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatase, Non-Receptor Type 11
Citation
APA
Chicago
ICMJE
MLA
NLM
Lee, K. M., Chuang, E., Griffin, M., Khattri, R., Hong, D. K., Zhang, W., … Bluestone, J. A. (1998). Molecular basis of T cell inactivation by CTLA-4. Science, 282(5397), 2263–2266. https://doi.org/10.1126/science.282.5397.2263
Lee, K. M., E. Chuang, M. Griffin, R. Khattri, D. K. Hong, W. Zhang, D. Straus, L. E. Samelson, C. B. Thompson, and J. A. Bluestone. “Molecular basis of T cell inactivation by CTLA-4.” Science 282, no. 5397 (December 18, 1998): 2263–66. https://doi.org/10.1126/science.282.5397.2263.
Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, et al. Molecular basis of T cell inactivation by CTLA-4. Science. 1998 Dec 18;282(5397):2263–6.
Lee, K. M., et al. “Molecular basis of T cell inactivation by CTLA-4.” Science, vol. 282, no. 5397, Dec. 1998, pp. 2263–66. Pubmed, doi:10.1126/science.282.5397.2263.
Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. Molecular basis of T cell inactivation by CTLA-4. Science. 1998 Dec 18;282(5397):2263–2266.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 18, 1998
Volume
282
Issue
5397
Start / End Page
2263 / 2266
Location
United States
Related Subject Headings
- src Homology Domains
- Transfection
- T-Lymphocytes
- Signal Transduction
- SH2 Domain-Containing Protein Tyrosine Phosphatases
- Recombinant Fusion Proteins
- Receptors, Antigen, T-Cell
- Protein Tyrosine Phosphatases
- Protein Tyrosine Phosphatase, Non-Receptor Type 6
- Protein Tyrosine Phosphatase, Non-Receptor Type 11