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Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.

Publication ,  Journal Article
Zhu, M; Liu, Y; Koonpaew, S; Granillo, O; Zhang, W
Published in: J Exp Med
October 18, 2004

Linker for activation of B cells (LAB, also called NTAL; a product of wbscr5 gene) is a newly identified transmembrane adaptor protein that is expressed in B cells, NK cells, and mast cells. Upon BCR activation, LAB is phosphorylated and interacts with Grb2. LAB is capable of rescuing thymocyte development in LAT-deficient mice. To study the in vivo function of LAB, LAB-deficient mice were generated. Although disruption of the Lab gene did not affect lymphocyte development, it caused mast cells to be hyperresponsive to stimulation via the FcepsilonRI, evidenced by enhanced Erk activation, calcium mobilization, degranulation, and cytokine production. These data suggested that LAB negatively regulates mast cell function. However, mast cells that lacked both linker for activation of T cells (LAT) and LAB proteins had a more severe block in FcepsilonRI-mediated signaling than LAT(-/-) mast cells, demonstrating that LAB also shares a redundant function with LAT to play a positive role in FcepsilonRI-mediated signaling.

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Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

October 18, 2004

Volume

200

Issue

8

Start / End Page

991 / 1000

Location

United States

Related Subject Headings

  • Tyrosine
  • Type C Phospholipases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, IgE
  • Phosphorylation
  • Phosphoproteins
  • Phospholipase C gamma
  • Mitogen-Activated Protein Kinases
  • Mice, Inbred C57BL
 

Citation

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Zhu, M., Liu, Y., Koonpaew, S., Granillo, O., & Zhang, W. (2004). Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med, 200(8), 991–1000. https://doi.org/10.1084/jem.20041223
Zhu, Minghua, Yan Liu, Surapong Koonpaew, Olivia Granillo, and Weiguo Zhang. “Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.J Exp Med 200, no. 8 (October 18, 2004): 991–1000. https://doi.org/10.1084/jem.20041223.
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991–1000.
Zhu, Minghua, et al. “Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.J Exp Med, vol. 200, no. 8, Oct. 2004, pp. 991–1000. Pubmed, doi:10.1084/jem.20041223.
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med. 2004 Oct 18;200(8):991–1000.

Published In

J Exp Med

DOI

ISSN

0022-1007

Publication Date

October 18, 2004

Volume

200

Issue

8

Start / End Page

991 / 1000

Location

United States

Related Subject Headings

  • Tyrosine
  • Type C Phospholipases
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, IgE
  • Phosphorylation
  • Phosphoproteins
  • Phospholipase C gamma
  • Mitogen-Activated Protein Kinases
  • Mice, Inbred C57BL