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Prenatal screening for thrombophilia: the background and the approach.

Publication ,  Journal Article
James, AH; Brancazio, LR
Published in: Gynecol Obstet Invest
2005

Coagulation is a normal response to blood vessel injury and involves the interaction of endothelium, platelets and clotting factors. Coagulation is altered by pregnancy and may be further altered by thrombophilia, an acquired or inherited predisposition to develop thrombosis. An overview of coagulation is provided as background for understanding thrombophilia. Both acquired and genetic risk factors for thrombosis are discussed. Thrombosis may affect not only the maternal circulation, but the utero-placental-fetal circulation as well. The literature documenting the association between maternal thrombosis and thrombophilia is summarized, as is the recent data linking thrombophilia and poor pregnancy outcome. An approach to screening for thrombophilia is outlined and strategies for thromboprophylaxis are provided.

Duke Scholars

Published In

Gynecol Obstet Invest

DOI

ISSN

0378-7346

Publication Date

2005

Volume

60

Issue

1

Start / End Page

47 / 57

Location

Switzerland

Related Subject Headings

  • Thrombosis
  • Thrombophilia
  • Prenatal Diagnosis
  • Pregnancy Outcome
  • Pregnancy Complications, Hematologic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Mass Screening
  • Humans
  • Fibrinolysis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
James, A. H., & Brancazio, L. R. (2005). Prenatal screening for thrombophilia: the background and the approach. Gynecol Obstet Invest, 60(1), 47–57. https://doi.org/10.1159/000083484
James, Andra H., and Leo R. Brancazio. “Prenatal screening for thrombophilia: the background and the approach.Gynecol Obstet Invest 60, no. 1 (2005): 47–57. https://doi.org/10.1159/000083484.
James AH, Brancazio LR. Prenatal screening for thrombophilia: the background and the approach. Gynecol Obstet Invest. 2005;60(1):47–57.
James, Andra H., and Leo R. Brancazio. “Prenatal screening for thrombophilia: the background and the approach.Gynecol Obstet Invest, vol. 60, no. 1, 2005, pp. 47–57. Pubmed, doi:10.1159/000083484.
James AH, Brancazio LR. Prenatal screening for thrombophilia: the background and the approach. Gynecol Obstet Invest. 2005;60(1):47–57.
Journal cover image

Published In

Gynecol Obstet Invest

DOI

ISSN

0378-7346

Publication Date

2005

Volume

60

Issue

1

Start / End Page

47 / 57

Location

Switzerland

Related Subject Headings

  • Thrombosis
  • Thrombophilia
  • Prenatal Diagnosis
  • Pregnancy Outcome
  • Pregnancy Complications, Hematologic
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Mass Screening
  • Humans
  • Fibrinolysis