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High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model.

Publication ,  Journal Article
Sama, AA; Khan, SN; Myers, ER; Huang, RC; Cammisa, FP; Sandhu, HS; Lane, JM
Published in: Clin Orthop Relat Res
August 2004

The effect of alendronate on osteoclast and osteoblast function was studied in a novel spine pseudarthrosis model in rats. Sixty-three Sprague-Dawley rats were divided into three groups: control group (saline), therapeutic dose group (1 microg/kg/week), and one-log overdose group (10 microg/kg/week). Animals had L4-L5 posterior intertransverse process fusion with limited bone graft and were sacrificed at 2, 4, and 6 weeks. Manual palpation showed no notable differences among groups. Treatment group radiographic scores were equal to or better than control group scores and were higher than the overdose group at 2 and 6 weeks. Qualitatively, limited histologic remodeling and poor osteoclastic and osteoblastic function were noted in the alendronate treated groups. Quantitative histologic analysis showed fewer osteoclasts in the therapeutic and high-dose groups (p < 0.001). The percent osteoblasts per bone surface area was lower in the high-dose group (p < 0.05). The results suggest that the effect of alendronate was dose dependent and animal model dependent and that supranormal doses of alendronate had a deleterious effect on osteoclastic and osteoblastic function in this model.

Duke Scholars

Published In

Clin Orthop Relat Res

DOI

ISSN

0009-921X

Publication Date

August 2004

Issue

425

Start / End Page

135 / 142

Location

United States

Related Subject Headings

  • Wound Healing
  • Rats, Sprague-Dawley
  • Rats
  • Pseudarthrosis
  • Osteoclasts
  • Osteoblasts
  • Orthopedics
  • Male
  • Lumbar Vertebrae
  • Dose-Response Relationship, Drug
 

Citation

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Chicago
ICMJE
MLA
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Sama, A. A., Khan, S. N., Myers, E. R., Huang, R. C., Cammisa, F. P., Sandhu, H. S., & Lane, J. M. (2004). High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. Clin Orthop Relat Res, (425), 135–142. https://doi.org/10.1097/00003086-200408000-00018
Sama, Andrew A., Safdar N. Khan, Elizabeth R. Myers, Russel C. Huang, Frank P. Cammisa, Harvinder S. Sandhu, and Joseph M. Lane. “High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model.Clin Orthop Relat Res, no. 425 (August 2004): 135–42. https://doi.org/10.1097/00003086-200408000-00018.
Sama AA, Khan SN, Myers ER, Huang RC, Cammisa FP, Sandhu HS, et al. High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. Clin Orthop Relat Res. 2004 Aug;(425):135–42.
Sama, Andrew A., et al. “High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model.Clin Orthop Relat Res, no. 425, Aug. 2004, pp. 135–42. Pubmed, doi:10.1097/00003086-200408000-00018.
Sama AA, Khan SN, Myers ER, Huang RC, Cammisa FP, Sandhu HS, Lane JM. High-dose alendronate uncouples osteoclast and osteoblast function: a study in a rat spine pseudarthrosis model. Clin Orthop Relat Res. 2004 Aug;(425):135–142.
Journal cover image

Published In

Clin Orthop Relat Res

DOI

ISSN

0009-921X

Publication Date

August 2004

Issue

425

Start / End Page

135 / 142

Location

United States

Related Subject Headings

  • Wound Healing
  • Rats, Sprague-Dawley
  • Rats
  • Pseudarthrosis
  • Osteoclasts
  • Osteoblasts
  • Orthopedics
  • Male
  • Lumbar Vertebrae
  • Dose-Response Relationship, Drug