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Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.

Publication ,  Journal Article
Robinson, GA
Published in: Brain Res Mol Brain Res
May 1995

Antibodies to c-Jun, JunD, JunB, c-Fos, FosB and Krox-24 proteins were used to examine the expression of these transcription factors in identified adult rat retinal ganglion cells with regenerating axons in a peripheral nerve graft. First, expression in ganglion cells 1 month after graft placement was compared to expression in these neurons 5 to 6 months after grafting. Whereas strong c-Jun expression was seen in most ganglion cells one month after grafting, most 5- to 6-month ganglion cells showed only basal expression. The maintained nucleolar expression of FosB in both ganglion cell groups was the only other transcription factor seen. Second, transcription factor expression was examined in these short- and long-term regenerating neurons after a second axotomy caused by graft transection and compared to the effects of a single axotomy on expression in non-regenerating ganglion cells. Only c-Jun was re-expressed in the regenerating ganglion cells after re-axotomy.

Duke Scholars

Published In

Brain Res Mol Brain Res

DOI

ISSN

0169-328X

Publication Date

May 1995

Volume

30

Issue

1

Start / End Page

61 / 69

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Sciatic Nerve
  • Retinal Ganglion Cells
  • Rats, Inbred Strains
  • Rats
  • Proto-Oncogene Proteins c-jun
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Immunohistochemistry
 

Citation

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ICMJE
MLA
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Robinson, G. A. (1995). Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. Brain Res Mol Brain Res, 30(1), 61–69. https://doi.org/10.1016/0169-328x(94)00277-l
Robinson, G. A. “Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.Brain Res Mol Brain Res 30, no. 1 (May 1995): 61–69. https://doi.org/10.1016/0169-328x(94)00277-l.
Robinson GA. Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. Brain Res Mol Brain Res. 1995 May;30(1):61–9.
Robinson, G. A. “Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells.Brain Res Mol Brain Res, vol. 30, no. 1, May 1995, pp. 61–69. Pubmed, doi:10.1016/0169-328x(94)00277-l.
Robinson GA. Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. Brain Res Mol Brain Res. 1995 May;30(1):61–69.
Journal cover image

Published In

Brain Res Mol Brain Res

DOI

ISSN

0169-328X

Publication Date

May 1995

Volume

30

Issue

1

Start / End Page

61 / 69

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • Sciatic Nerve
  • Retinal Ganglion Cells
  • Rats, Inbred Strains
  • Rats
  • Proto-Oncogene Proteins c-jun
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Immunohistochemistry