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Adrenoceptors, uncoupling proteins, and energy expenditure.

Publication ,  Journal Article
Collins, S; Cao, W; Daniel, KW; Dixon, TM; Medvedev, AV; Onuma, H; Surwit, R
Published in: Exp Biol Med (Maywood)
December 2001

Interest in the biology of adipose tissue has undergone a revival in recent years with the discovery of a host of genes that contribute to the regulation of satiety and metabolic rate. The catecholamines have long been known to be key modulators of adipose tissue lipolysis and the hydrolysis of triglyceride energy stores. However, more recent efforts to understand the role of individual adrenergic receptor subtypes expressed in adipocytes and their signal transduction pathways have revealed a complexity not previously appreciated. Combined with this interest in the modulation of adipocyte metabolism is a renewed focus upon brown adipose tissue and the mechanisms of whole body thermogenesis in general. The discovery of novel homologs of the brown fat uncoupling protein (UCP) such as UCP2 and UCP3 has provoked intensive study of these mitochondrial proteins and the role that they play in fuel metabolism. The story of the novel UCPs has proven to be intriguing and still incompletely understood. Here, we review the status of adipose tissue from inert storage depot to endocrine organ, interesting signal transduction pathways triggered by beta-adrenergic receptors in adipocytes, the potential of these receptors for discriminating and coordinated metabolic regulation, and current views on the role of UCP2 and UCP3 based on physiological studies and gene knockout models.

Duke Scholars

Published In

Exp Biol Med (Maywood)

DOI

ISSN

1535-3702

Publication Date

December 2001

Volume

226

Issue

11

Start / End Page

982 / 990

Location

England

Related Subject Headings

  • Uncoupling Protein 3
  • Uncoupling Protein 2
  • Signal Transduction
  • Receptors, Adrenergic
  • Proteins
  • Models, Biological
  • Mitochondrial Proteins
  • Mice, Obese
  • Mice, Knockout
  • Mice
 

Citation

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Collins, S., Cao, W., Daniel, K. W., Dixon, T. M., Medvedev, A. V., Onuma, H., & Surwit, R. (2001). Adrenoceptors, uncoupling proteins, and energy expenditure. Exp Biol Med (Maywood), 226(11), 982–990. https://doi.org/10.1177/153537020122601104
Collins, S., W. Cao, K. W. Daniel, T. M. Dixon, A. V. Medvedev, H. Onuma, and R. Surwit. “Adrenoceptors, uncoupling proteins, and energy expenditure.Exp Biol Med (Maywood) 226, no. 11 (December 2001): 982–90. https://doi.org/10.1177/153537020122601104.
Collins S, Cao W, Daniel KW, Dixon TM, Medvedev AV, Onuma H, et al. Adrenoceptors, uncoupling proteins, and energy expenditure. Exp Biol Med (Maywood). 2001 Dec;226(11):982–90.
Collins, S., et al. “Adrenoceptors, uncoupling proteins, and energy expenditure.Exp Biol Med (Maywood), vol. 226, no. 11, Dec. 2001, pp. 982–90. Pubmed, doi:10.1177/153537020122601104.
Collins S, Cao W, Daniel KW, Dixon TM, Medvedev AV, Onuma H, Surwit R. Adrenoceptors, uncoupling proteins, and energy expenditure. Exp Biol Med (Maywood). 2001 Dec;226(11):982–990.
Journal cover image

Published In

Exp Biol Med (Maywood)

DOI

ISSN

1535-3702

Publication Date

December 2001

Volume

226

Issue

11

Start / End Page

982 / 990

Location

England

Related Subject Headings

  • Uncoupling Protein 3
  • Uncoupling Protein 2
  • Signal Transduction
  • Receptors, Adrenergic
  • Proteins
  • Models, Biological
  • Mitochondrial Proteins
  • Mice, Obese
  • Mice, Knockout
  • Mice