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Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology.

Publication ,  Journal Article
Polascik, TJ; Hamper, U; Lee, BR; Dai, Y; Hilton, J; Magee, CA; Crone, JK; Shue, MJ; Ferrell, M; Trapanotto, V; Adiletta, M; Partin, AW
Published in: Urology
March 1999

To evaluate the efficacy of interstitial saline radiofrequency energy for reproducibly ablating nonmalignant (control) and malignant (the VX-2 tumor) renal tissue in a rabbit model, and to determine the ability of conventional gray-scale and power sonography to image the tumor and ablative process in real time before, during, and after treatment.The VX-2 tumor was implanted beneath the renal capsule in 18 rabbit kidneys. Twelve days after implantation, 50 W of 500-kHz radiofrequency energy was delivered into the surgically externalized renal tumor and contralateral control kidney for 30 or 45-second treatment intervals using an interstitial saline-augmented radiofrequency probe (the virtual electrode). Localization of the tumor and response to treatment were imaged with gray-scale and power Doppler ultrasonography. The effect of radiofrequency and extent of the destructive process on benign and malignant renal tissue were evaluated histologically.Mean tumor size was 1.3 x 0.7 cm. Both 30 and 45-second treatment intervals provided marked tissue/tumor ablation. Gross anatomic and histologic analysis showed time-dependent ablated lesions averaging 1.4+/-0.3 x 1.0+/-0.3 cm (30-second treatment) and 1.8+/-0.4 x 1.5+/-0.3 cm (45-second treatment), with clear demarcation of the surrounding parenchyma. Conventional gray-scale sonography allowed visualization of the ablative process, and power Doppler ultrasound demonstrated changes in the vascular pattern of the tumor both before and after ablation. No immediate treatment-related complications were observed.These preliminary studies in a rabbit model demonstrate the feasibility of using the interstitial saline-augmented electrode to ablate small renal tumors and the ability to simultaneously visualize the ablative process using real-time ultrasonography. This technology may have the potential to treat small renal tumors in a minimally invasive manner in the clinical setting.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

ISSN

0090-4295

Publication Date

March 1999

Volume

53

Issue

3

Start / End Page

465 / 472

Related Subject Headings

  • Urology & Nephrology
  • Sodium Chloride
  • Rabbits
  • Kidney Neoplasms
  • Evaluation Studies as Topic
  • Electrosurgery
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
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MLA
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Polascik, T. J., Hamper, U., Lee, B. R., Dai, Y., Hilton, J., Magee, C. A., … Partin, A. W. (1999). Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology. Urology, 53(3), 465–472. https://doi.org/10.1016/s0090-4295(98)00651-7
Polascik, T. J., U. Hamper, B. R. Lee, Y. Dai, J. Hilton, C. A. Magee, J. K. Crone, et al. “Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology.Urology 53, no. 3 (March 1999): 465–72. https://doi.org/10.1016/s0090-4295(98)00651-7.
Polascik TJ, Hamper U, Lee BR, Dai Y, Hilton J, Magee CA, et al. Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology. Urology. 1999 Mar;53(3):465–72.
Polascik, T. J., et al. “Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology.Urology, vol. 53, no. 3, Mar. 1999, pp. 465–72. Epmc, doi:10.1016/s0090-4295(98)00651-7.
Polascik TJ, Hamper U, Lee BR, Dai Y, Hilton J, Magee CA, Crone JK, Shue MJ, Ferrell M, Trapanotto V, Adiletta M, Partin AW. Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology. Urology. 1999 Mar;53(3):465–472.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

ISSN

0090-4295

Publication Date

March 1999

Volume

53

Issue

3

Start / End Page

465 / 472

Related Subject Headings

  • Urology & Nephrology
  • Sodium Chloride
  • Rabbits
  • Kidney Neoplasms
  • Evaluation Studies as Topic
  • Electrosurgery
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences