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Transcription of class III genes: formation of preinitiation complexes.

Publication ,  Journal Article
Lassar, AB; Martin, PL; Roeder, RG
Published in: Science
November 18, 1983

Class III genes require multiple cellular factors for transcription by RNA polymerase III; these genes form stable transcription complexes, which in the case of Xenopus 5S genes are correlated with differential expression in vivo. The minimal number and identity of the factors required to form both stable and metastable complexes on three class III genes (encoding, respectively, 5S RNA, transfer RNA, and adenovirus VA RNA species) were determined. Stable complex formation requires one common factor, whose recognition site was analyzed, and either no additional factors (the VA gene), a second common factor (the transfer RNA gene), or a third gene-specific factor (the 5S gene). The mechanism of stable complex formation and its relevance to transcriptional regulation were examined in light of the various factors and the promoter sequences recognized by these factors.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 18, 1983

Volume

222

Issue

4625

Start / End Page

740 / 748

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • RNA, Viral
  • RNA, Transfer
  • RNA, Ribosomal
  • RNA Polymerase III
  • Operon
  • Humans
  • Genes
  • General Science & Technology
 

Citation

APA
Chicago
ICMJE
MLA
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Lassar, A. B., Martin, P. L., & Roeder, R. G. (1983). Transcription of class III genes: formation of preinitiation complexes. Science, 222(4625), 740–748. https://doi.org/10.1126/science.6356356
Lassar, A. B., P. L. Martin, and R. G. Roeder. “Transcription of class III genes: formation of preinitiation complexes.Science 222, no. 4625 (November 18, 1983): 740–48. https://doi.org/10.1126/science.6356356.
Lassar AB, Martin PL, Roeder RG. Transcription of class III genes: formation of preinitiation complexes. Science. 1983 Nov 18;222(4625):740–8.
Lassar, A. B., et al. “Transcription of class III genes: formation of preinitiation complexes.Science, vol. 222, no. 4625, Nov. 1983, pp. 740–48. Pubmed, doi:10.1126/science.6356356.
Lassar AB, Martin PL, Roeder RG. Transcription of class III genes: formation of preinitiation complexes. Science. 1983 Nov 18;222(4625):740–748.

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 18, 1983

Volume

222

Issue

4625

Start / End Page

740 / 748

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • RNA, Viral
  • RNA, Transfer
  • RNA, Ribosomal
  • RNA Polymerase III
  • Operon
  • Humans
  • Genes
  • General Science & Technology